The Kallikrein-kinin System in Non-tetrapod Vertebrates

小行星9418819 在包括人类在内的哺乳动物中，特定的酶（激肽释放酶）切割循环蛋白（激肽原）以产生小肽（缓激肽），其参与调节血流以及神经元和平滑肌活性。 这个过程被称为激肽释放酶-激肽系统，但不知道该系统何时在进化中出现，也不知道它是否在非哺乳类脊椎动物中发挥重要的功能作用。 康伦博士建议检查血浆样本从广泛的水生脊椎动物在不同的进化水平的存在下的组成部分的系统。 他已经从鳟鱼和古老的鱼类弓鳍鱼中纯化出新型缓激肽相关肽，他建议系统地研究这些肽在其物种起源中的生物活性。 Conlon博士将使用长期插管动物研究对心血管参数的影响，并使用分离的组织制备物确定肽的靶位点。 这些数据将允许在鱼的激肽释放酶-激肽系统的生理重要性的评估。 ***

9418819 Conlon In mammals, including the human, specific enzymes (kallikreins) cleave a circulating protein (kininogen) to generate a small peptide (bradykinin) that is involved in regulating blood flow and both neuronal and smooth muscle activity. This process is referred to as the kallikrein-kinin system but it is not known when the system arose in evolution or whether it plays an important functional role in non-mammalian vertebrates. Dr. Conlon proposes to examine plasma samples from a wide range of aquatic vertebrates at different levels of evolution for the presence of the components of the system. He has already purified novel bradykinin-related peptides from the trout and from the phylogentically ancient fish, the bowfin, and he proposes to systematically investigate the biological activities of the peptides in their species of origin. Dr. Conlon will study effects on cardiovascular parameters using chronically cannulated animals and identify target sites for the peptides using isolated tissue preparations. The data will permit an assessment of the physiological importance of the kallikrein-kinin system in fish. ***