Novel Treatments for Lysosomal Neurological Disorders: Targeting Microglia Cells and Missfolded Proteins for Therapy of Mucopolysaccharidosis IIIC
溶酶体神经疾病的新疗法:靶向小胶质细胞和错误折叠蛋白治疗粘多糖贮积症 IIIC
基本信息
- 批准号:366613
- 负责人:
- 金额:$ 7.29万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2016
- 资助国家:加拿大
- 起止时间:2016-11-01 至 2017-11-01
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Sanfilippo disease belongs to a group of devastating inherited diseases of children affecting the lysosome, a cellular compartment responsible for degradation and recycling of big biological molecules. It causes rapid mental retardation in infants and ch
圣菲利波病属于一组破坏性遗传性疾病的儿童影响溶酶体,细胞室负责降解和回收大生物分子。 它会导致婴儿和儿童的快速智力迟钝,
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Pshezhetsky Alexey V其他文献
Pshezhetsky Alexey V的其他文献
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{{ truncateString('Pshezhetsky Alexey V', 18)}}的其他基金
Neuroprotective peptides for treatment of neurological lysosomal diseases
用于治疗神经溶酶体疾病的神经保护肽
- 批准号:
452819 - 财政年份:2021
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
Neuroprotective peptides for treatment of neurological lysosomal diseases
用于治疗神经溶酶体疾病的神经保护肽
- 批准号:
438024 - 财政年份:2020
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
Novel Treatments for Lysosomal Neurological Disorders: Targeting Microglia Cells and Misfolded Proteins for Therapy of Mucopolysaccharidosis IIIC
溶酶体神经疾病的新疗法:靶向小胶质细胞和错误折叠蛋白治疗粘多糖贮积症 IIIC
- 批准号:
369322 - 财政年份:2017
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
Neuraminidase 1 as a trigger of immune thrombocytopenia: using animal models to understand pathophysiology of the disease and develop novel therapies.
神经氨酸酶 1 作为免疫性血小板减少症的触发因素:利用动物模型了解该疾病的病理生理学并开发新疗法。
- 批准号:
346871 - 财政年份:2016
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
Mucopolysaccharidosis IIIC as a protein folding disease: using animal models to study pathophysiology and explore potential therapeutic solutions
粘多糖贮积症 IIIC 作为一种蛋白质折叠疾病:利用动物模型研究病理生理学并探索潜在的治疗方案
- 批准号:
210690 - 财政年份:2010
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
Serine carboxypeptidases that inactivate short vasoactive peptides: roles in vasoconstriction and proliferation of vascular SMCs
灭活短血管活性肽的丝氨酸羧肽酶:在血管收缩和血管平滑肌细胞增殖中的作用
- 批准号:
180360 - 财政年份:2009
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
Carboxypeptidases that inactivate short vasoactive peptides: roles in vasoconstriction and proliferation of vascular SMCs
灭活短血管活性肽的羧肽酶:在血管收缩和血管 SMC 增殖中的作用
- 批准号:
183796 - 财政年份:2008
- 资助金额:
$ 7.29万 - 项目类别:
Operating Grants
相似海外基金
CAREER: Diagnosing the Undiagnosable: Using Enzyme Upregulation to Probe Cellular Behavior in Neuropathic Lysosomal Storage Disease
职业:诊断无法诊断的疾病:利用酶上调来探测神经性溶酶体贮积病的细胞行为
- 批准号:
2047697 - 财政年份:2021
- 资助金额:
$ 7.29万 - 项目类别:
Continuing Grant
Role of the interaction between microglia and neuron in the defected neuronal function in the lysosomal storage disease
小胶质细胞和神经元之间的相互作用在溶酶体贮积病神经元功能缺陷中的作用
- 批准号:
20K06857 - 财政年份:2020
- 资助金额:
$ 7.29万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Investigating lipid homeostasis using haploid genetics in lysosomal storage disease and cancer
使用单倍体遗传学研究溶酶体贮积病和癌症中的脂质稳态
- 批准号:
392251 - 财政年份:2018
- 资助金额:
$ 7.29万 - 项目类别:
Fellowship Programs
Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis
溶酶体贮积病胱氨酸中毒的分子和细胞机制
- 批准号:
10801704 - 财政年份:2017
- 资助金额:
$ 7.29万 - 项目类别:
Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis
溶酶体贮积病胱氨酸中毒的分子和细胞机制
- 批准号:
10434057 - 财政年份:2017
- 资助金额:
$ 7.29万 - 项目类别:
Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis
溶酶体贮积病胱氨酸中毒的分子和细胞机制
- 批准号:
10683169 - 财政年份:2017
- 资助金额:
$ 7.29万 - 项目类别:
Pathophysiology of lysosomal storage disease and lysophagy
溶酶体贮积病和溶食的病理生理学
- 批准号:
15H05673 - 财政年份:2015
- 资助金额:
$ 7.29万 - 项目类别:
Grant-in-Aid for Young Scientists (A)
Development of efficient enzyme replacement therapy for lysosomal storage disease with immune modulation
通过免疫调节开发有效的酶替代疗法治疗溶酶体贮积症
- 批准号:
15K09600 - 财政年份:2015
- 资助金额:
$ 7.29万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Anti-CD3 antibody induced immune tolerance to infused enzyme in enzyme replacement therapy for lysosomal storage disease
抗 CD3 抗体在溶酶体贮积病酶替代疗法中诱导对输注酶的免疫耐受
- 批准号:
21591333 - 财政年份:2009
- 资助金额:
$ 7.29万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of a unique plant-based screening system to identify pharmacological chaperons for treatment of a rare human lysosomal storage disease
开发独特的植物筛选系统来识别药理学伴侣,用于治疗罕见的人类溶酶体贮积症
- 批准号:
383425-2009 - 财政年份:2009
- 资助金额:
$ 7.29万 - 项目类别:
University Undergraduate Student Research Awards