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Regulation and impact of productive AID targeting during antibody responses.

Regulation and impact of productive AID targeting during antibody responses.
抗体反应期间生产性 AID 靶向的调节和影响。
批准号：
371031
负责人：
Di Noia Javier M
金额：
$64.09万
依托单位：
Institut de recherches cliniques de Montral
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=371031&lang=en
关键词：
Activation Induced Deaminase Antibody Responses Apobec Class Switch Recombination Germinal Center B Cells Somatic Hypermutation

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中文摘要
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英文摘要
Antibodies are a major component of the human immune system. A large repertoire of specialized cells named B-lymphocytes, each producing a different antibody, are constantly renewed to be able to detect any of innumerable and constantly evolving pathogens
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Molecular mechanisms underlying high-affinity and isotype switched antibody responses
Regulation of germinal center B cell function during antibody responses
DNA deamination in adaptive and innate immunity: 20 years after the discovery of Activation induced deaminase
Coordinating DNA deamination, double strand break and repair to prevent genomic instability during antibody gene diversification.
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