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DNA deamination in adaptive and innate immunity: 20 years after the discovery of Activation induced deaminase

DNA deamination in adaptive and innate immunity: 20 years after the discovery of Activation induced deaminase
适应性和先天免疫中的 DNA 脱氨作用：发现激活诱导脱氨酶 20 年后
批准号：
411857
负责人：
Di Noia Javier M
金额：
$0.73万
依托单位：
Institut de recherches cliniques de Montral
依托单位国家：
加拿大
项目类别：
Miscellaneous Programs
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-09-01 至 2020-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=411857&lang=en
关键词：
Antibodies Hematological Cancer Immune Response Immunological Memory Mutation

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中文摘要
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英文摘要
This meeting attracts scientists studying of a unique type of enzymes that edit the genome of cells and viruses. In 2020 we mark the 20th anniversary of the landmark discovery that the enzyme Activation induced deaminase (AID) underpins antibody-mediated
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Molecular mechanisms underlying high-affinity and isotype switched antibody responses
Regulation of germinal center B cell function during antibody responses
Regulation and impact of productive AID targeting during antibody responses.
Coordinating DNA deamination, double strand break and repair to prevent genomic instability during antibody gene diversification.
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