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Coordinating DNA deamination, double strand break and repair to prevent genomic instability during antibody gene diversification.

Coordinating DNA deamination, double strand break and repair to prevent genomic instability during antibody gene diversification.
协调 DNA 脱氨基、双链断裂和修复，以防止抗体基因多样化过程中基因组不稳定。
批准号：
280743
负责人：
Di Noia Javier M
金额：
$38.5万
依托单位：
Institut de recherches cliniques de Montral
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2013
资助国家：
加拿大
项目状态：
已结题
起止时间：
2013-03-01 至 2017-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=280743&lang=en
关键词：
Activation Induced Deaminase Chromosomal Translocations Class Switch Recombination Dna Double Strand Breaks Genomic Instability Non-Homologous End Joining Somatic Hypermutation Uracil Dna Glycosylase

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英文摘要
Antibodies can recognize and eliminate any pathogen or toxin. Since pathogens are virtually infinite, antibodies need to adapt. To do this, almost every B lymphocyte modifies the genes that encode its antibody in two regions. One is the region that binds
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Molecular mechanisms underlying high-affinity and isotype switched antibody responses
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