Neuroanatomical Basis of Endocrine-Mediated Behavioral Development in the Honey Bee

建议#9423164苏珊·E·法尔巴赫，少年派基因·E·罗宾逊，共同的少年派行为发育存在于许多物种中，包括人类。随着个体年龄的增长和经历生命的不同阶段，他们对特定环境刺激的遗传决定的行为反应会以可预测的方式发生变化。通常，这些变化涉及到越来越复杂的行为反应，涉及学习。Fahrbach博士和Robinson博士的目标是了解大脑结构的变化如何与行为的发展相关，特别是以高度可塑性为特征的行为。Fahrbach博士和Robinson博士将测试两个解释神经解剖可塑性和行为可塑性作用的假说。第一种假设预测，大脑结构的变化发生在行为变化的预期中，可能是特定的神经内分泌信号的结果。根据这一假设，神经解剖学的变化对于支持向更复杂的行为的转变是必要的。第二种假设预测，大脑结构的变化是行为变化的结果。根据这一假设，神经解剖学的变化对于支持更复杂的行为的持续表现是必要的。Fahrbach博士和Robinson博士将在实验中操纵内分泌和经验因素后，通过研究昆虫的大脑结构来探索这些假设。将对大脑区域体积、突触形成和导致神经可塑性的分子事件进行研究。这项研究的主要意义将是有助于我们理解激素介导的成年动物和人类行为可塑性的神经解剖学基础。

Proposal # 9423164 Susan E. Fahrbach, PI Gene E. Robinson, co-PI Behavioral development occurs in many species, including humans. As individuals age and pass through different stages of their life, their genetically determined behavioral responses to specific environmental stimuli change in predictable ways. Often these changes involve increasingly complex behavioral responses that involve learning. The goal of Drs. Fahrbach and Robinson is to understand how changes in brain structure relate to the development of behavior, particularly behavior that is characterized by a high degree of plasticity. Dr. Fahrbach and Dr. Robinson will test two hypotheses that explain the role of neuroanatomical plasticity and behavioral plasticity. The first hypothesis predicts that changes in brain structure occur in anticipation of changes in behavior, perhaps as a result of a specific neuroendocrine signal. According to this hypothesis, the neuroanatomical changes are necessary to support the transition to a more complex behavior. The second hypothesis predicts that changes in brain structure occur as a consequence of changes in behavior. According to this hypothesis, the neuroanatomical changes are necessary to support the continued performance of a more complex behavior. Drs. Fahrbach and Robinson will explore these hypotheses by studying brain structures insects after endocrine and experiential factors are experimentally manipulated. Studies of brain region volumes, synapse formation and molecular events leading to neural plasticity will be undertaken. The principal significance of this research will be to contribute to our understanding of the neuroanatomical basis for hormone-mediated behavioral plasticity in adult animals and humans.