NSF Young Investigator: Transition Metal Heteroatom Bonds

美国国家科学基金会无机、生物无机和有机金属项目青年研究员奖将支持耶鲁大学化学系John F. Hartwig博士对含杂原子过渡金属化合物的研究。该研究的目的是将有机金属化合物的催化有效性和稳定性带到化学的新领域。有机金属化合物含有金属-碳键；在这里，将合成含有金属-硼键的新物种，并研究它们作为催化剂和新材料起始材料的潜力。钨、铌、铁、钌、铱和镓化合物将被制备，重点将放在烯烃反应的催化。此外，还将研究金属介导的碳氮和碳氧的催化偶联。金属-氮系统的研究工作还将涉及使用有机金属化合物与肽和DNA，其中金属-氮键的光解裂解将有助于识别分子内蛋白质折叠过程和其他蛋白质-蛋白质或蛋白质-DNA关联。

This NSF Young Investigator Award in the Inorganic, Bioinorganic, and Organometallic Program will support research on transition metal compounds with heteroatoms by Dr. John F. Hartwig of the Chemistry Department, Yale University. The goal of the research is to bring the catalytic effectiveness and stability of organometallic compounds to new areas of chemistry. Organometallic compounds contain metal-carbon bonds; here new species which also contain metal-boron bonds will be synthesized and studied for their potential as catalysts and as starting materials for new materials. Tungsten, niobium, iron, ruthenium, iridium and gallium compounds will be prepred and emphasis will be placed on catalysis of reactions of alkenes. In addition, catalytic metal-mediated coupling of carbon and nitrogen and of carbon and oxygen will be studied. Work on metal-nitrogen systems will also involve use of organometallic compounds with peptides and DNA in which photolytic cleavage of the metal-nitrogen bond will aid in the identification of intramolecular protein folding processes and other protein-protein or protein-DNA associations.