SusChEM: Mechanism and Discovery of Metal-Catalyzed Fluoroalkylation Reactions
SusChEM:金属催化氟烷基化反应的机理和发现
基本信息
- 批准号:1565886
- 负责人:
- 金额:$ 68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-05-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The Chemical Catalysis Program of the Chemistry Division supports the project by Professor John F. Hartwig in the Department of Chemistry at the University of California, Berkeley. In this program, Professor Hartwig is developing a mechanistic understanding of catalytic reactions that use transition metal complexes bonded to fluorine-containing alkyl groups. These studies answer a series of questions about the impact of fluorine atoms on the metal-bound carbon atom. The studies also assess several approaches to control the reactivity of these fluoroalkyl complexes of transition metals. By developing methods to control the reactivity of fluoroalkyl complexes, this research enables the development of new catalytic reactions that add fluoroalkyl groups into organic molecules. Organic molecules containing fluorine are vital to materials, agricultural, and medicinal sciences. For example, over 20% of new pharmaceuticals and 25% of licensed herbicides contain fluorine. The project is well suited for providing a broad education to Ph.D. scientists and undergraduates, including those of underrepresented groups. A series of outreach activities for K-12 students, the general public, and the general scientific community are part of Professor Hartwig's efforts resulting from the research program.Although a large fraction of pharmaceuticals and agrochemicals contain fluorine, fluorinated structures are largely limited to those derived from simple fluoroarenes, trifluoromethylarenes or trifluoroacetates. Many of the potential methods to synthesize more diverse structures containing fluoroalkyl groups require new approaches to induce and control the reactivity of fluoroalkyl transition-metal complexes in catalytic reactions. This research creates these capabilities by demonstrating, by a combination of kinetic analysis of catalytic reactions and synthesis of catalytic intermediates, how to induce productive reactivity in fluoroalkyl complexes of palladium. This project also creates new catalytic reactions that couple partially fluorinated alkyl groups to aromatic and heteroaromatic molecules to form products that are difficult to access by current synthetic methods. With this information, fluoroalkylation reactions that are currently stoichiometric are being made catalytic. Additionally, new reactions of aryl halides that form fluoroalkylarenes with novel structures that are difficult to prepare by alternative methods are being created. This research enables the preparation of new classes of fluorinated molecules for materials science, medicinal chemistry, and agroscience. As part of the educational plan, Professor Hartwig teaches short-courses for those lacking formal training in organometallic catalysis, co-authors a sophomore organic text that includes content on catalysis in medicinal and green organic chemistry, and delivers lectures to general audiences, predominantly in forums in which he reaches potential scientists from underrepresented groups.
化学部的化学催化计划支持加州大学伯克利分校化学系约翰·F·哈特威格教授的项目。在这个项目中,哈特威格教授正在发展对使用连接到含氟烷基的过渡金属络合物的催化反应的机理的理解。这些研究回答了有关氟原子对金属结合碳原子的影响的一系列问题。这些研究还评估了控制这些过渡金属氟烷基络合物反应性的几种方法。通过开发控制氟烷基络合物反应性的方法,这项研究使向有机分子中添加氟烷基团的新催化反应的发展成为可能。含氟的有机分子对材料、农业和医药科学都是至关重要的。例如,超过20%的新药和25%的特许除草剂含有氟。该项目非常适合为博士科学家和本科生提供广泛的教育,包括那些代表性不足的群体。针对K-12学生、普通公众和普通科学界的一系列推广活动是哈特威格教授在研究计划中做出的努力的一部分。尽管很大一部分药品和农用化学品含有氟,但氟化结构在很大程度上仅限于那些来自简单的氟芳烃、三氟甲基芳烃或三氟乙酸酯的结构。许多合成含氟烷基结构更多样的潜在方法需要新的方法来诱导和控制氟烷基过渡金属络合物在催化反应中的反应活性。这项研究通过结合催化反应的动力学分析和催化中间体的合成,展示了如何在钯的氟烷基络合物中诱导产生反应性,从而创造了这些能力。该项目还创造了新的催化反应,将部分氟化的烷基偶联到芳香族和杂芳族分子上,形成目前合成方法难以获得的产品。有了这些信息,目前化学计量比的氟烷基化反应正在被催化。此外,正在创造芳基卤化物的新反应,这些反应形成具有新结构的氟代烷基芳烃,这些结构很难用替代方法制备。这项研究使材料科学、药物化学和农业科学的新型氟化分子的制备成为可能。作为教育计划的一部分,哈特威格教授为那些缺乏有机金属催化正规培训的人教授短期课程,与人合著一本二年级的有机课本,其中包括药物和绿色有机化学中的催化内容,并向普通听众讲课,主要是在论坛上,他接触到来自代表性不足群体的潜在科学家。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John Hartwig其他文献
Recipes for excess
过剩的食谱
- DOI:
10.1038/437487a - 发表时间:
2005-09-21 - 期刊:
- 影响因子:48.500
- 作者:
John Hartwig - 通讯作者:
John Hartwig
The actin-based motility of Shigella flexneri requires N-WASP
- DOI:
10.1016/s0016-5085(00)83848-2 - 发表时间:
2000-04-01 - 期刊:
- 影响因子:
- 作者:
Fuminao Takeshima;Frederick W. Alt;Ching-Hui Liu;John Hartwig;Fred S. Rosen;Marcia Goldberg;Fred Southwick;Scott B. Snapper - 通讯作者:
Scott B. Snapper
Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation: Presented in part at the XVIIth Congress of the International Society on Thrombosis and Haemostasis, Washington, DC, August 14-21, 1999.
- DOI:
10.1182/blood.v95.8.2600 - 发表时间:
2000-04-15 - 期刊:
- 影响因子:
- 作者:
Malgorzata B. Sobocka;Tomasz Sobocki;Probal Banerjee;Cipora Weiss;Julie I. Rushbrook;Allen J. Norin;John Hartwig;Moro O. Salifu;Mariana S. Markell;Anna Babinska;Yigal H. Ehrlich;Elizabeth Kornecki - 通讯作者:
Elizabeth Kornecki
John Hartwig的其他文献
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{{ truncateString('John Hartwig', 18)}}的其他基金
Mechanism and Discovery of Metal-Catalyzed Fluoroalkylation Reactions
金属催化氟烷基化反应的机理和发现
- 批准号:
2350331 - 财政年份:2024
- 资助金额:
$ 68万 - 项目类别:
Standard Grant
Biosynthetic Pathways with Artificial Metalloenzymes
人工金属酶的生物合成途径
- 批准号:
2027943 - 财政年份:2020
- 资助金额:
$ 68万 - 项目类别:
Continuing Grant
Mechanism and Discovery of Metal-Catalyzed Fluoroalkylation Reactions
金属催化氟烷基化反应的机理和发现
- 批准号:
1955635 - 财政年份:2020
- 资助金额:
$ 68万 - 项目类别:
Continuing Grant
Catalytic Regioselective Functionalization of Alkane and Arenes
烷烃和芳烃的催化区域选择性官能化
- 批准号:
1213409 - 财政年份:2012
- 资助金额:
$ 68万 - 项目类别:
Standard Grant
Catalytic Regioselective Functionalization of Alkane and Arenes
烷烃和芳烃的催化区域选择性官能化
- 批准号:
1156496 - 财政年份:2011
- 资助金额:
$ 68万 - 项目类别:
Continuing Grant
Catalytic Regioselective Functionalization of Alkane and Arenes
烷烃和芳烃的催化区域选择性官能化
- 批准号:
0910641 - 财政年份:2009
- 资助金额:
$ 68万 - 项目类别:
Continuing Grant
Catalytic, Regioselective Functionalization of Alkane and Arenes
烷烃和芳烃的催化、区域选择性官能化
- 批准号:
0606685 - 财政年份:2006
- 资助金额:
$ 68万 - 项目类别:
Continuing Grant
Catalytic, Regioselective Functionalization of Alkane and Arenes
烷烃和芳烃的催化、区域选择性官能化
- 批准号:
0653335 - 财政年份:2006
- 资助金额:
$ 68万 - 项目类别:
Continuing Grant
Catalytic Enantioselective Allyic Amination and Etherification
催化对映选择性烯丙胺化和醚化
- 批准号:
0652280 - 财政年份:2006
- 资助金额:
$ 68万 - 项目类别:
Standard Grant
Catalytic Enantioselective Allyic Amination and Etherification
催化对映选择性烯丙胺化和醚化
- 批准号:
0414542 - 财政年份:2004
- 资助金额:
$ 68万 - 项目类别:
Standard Grant
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