Catalytic Regioselective Functionalization of Alkane and Arenes

这项无机化学、生物无机化学和金属有机化学计划的研究奖支持伊利诺伊大学厄巴纳-香槟分校的约翰·F·哈特威格教授在典型的非活性C-H键上开发反应。这项工作将创造新的方法，通过在大多数试剂的惰性位置进行选择性化学转化来制备有机分子。含有过渡金属和硼之间键的络合物催化这些反应，这项研究将揭示导致这种不寻常反应活性的过渡金属的性质。这些络合物催化的反应已经并将继续应用于合成具有新性质的聚合物、发光能力增强的有机分子、用于其他反应的催化剂的组成以及用于理解生物体系的有机探针。拟议研究产生的工作是课堂新课程、短期课程、许多外部讲座和一个主要教科书项目的一部分，该项目将在下一个赠款期间由PI完成。这项研究将导致以更少的步骤、更少的浪费、更少对官能团的安装和保护的依赖来进行化学合成的新方法。此外，这项研究创建了潜在的原则，未来的催化剂和工艺设计的基础上，更有效的合成。研究如何确定金属的电子性质以及反应性配体的亲电或亲核性质如何影响C-H键的断裂和官能化将产生这些原理。

This research award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor John F. Hartwig at the University of Illinois at Urbana-Champaign to develop reactions at typically unreactive C-H bonds. This work will create new methods to prepare organic molecules by selective chemical transformations at positions that are inert to most reagents. Complexes containing bonds between transition metals and boron catalyze these reactions, and this grant will reveal the properties of the transition metal that lead to this unusual reactivity. The reactions catalyzed by these complexes have been and will continue to be applied to the synthesis of polymers containing new properties, organic molecules with enhanced abilities to emit light, components of catalysts for other reactions, and organic probes for understanding biological systems. Work emanating from the proposed research is part of new curricula for the classroom, short-courses, many external lectures, and a major textbook project that will be completed in the next grant period by the PI.This research will lead to new methods to conduct chemical synthesis in fewer steps, with less waste, and with less reliance on the installation and protection of functional groups. In addition, this research creates the underlying principles on which future design of catalysts and processes for more efficient synthesis are based. Studies to define how the electronic properties of the metal and how electrophilic or nucleophilic properties of the reactive ligand affect C-H bond cleavage and functionalization will create these principles.