Catalytic Regioselective Functionalization of Alkane and Arenes

烷烃和芳烃的催化区域选择性官能化

• 批准号: 0910641
• 负责人: John Hartwig
• 金额: $ 51.6万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0910641&HistoricalAwards=false
• 关键词: Catalytic; Regioselective; Functionalization; Alkane; Arenes

This research award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor John F. Hartwig at the University of Illinois at Urbana-Champaign to develop reactions at typically unreactive C-H bonds. This work will create new methods to prepare organic molecules by selective chemical transformations at positions that are inert to most reagents. Complexes containing bonds between transition metals and boron catalyze these reactions, and this grant will reveal the properties of the transition metal that lead to this unusual reactivity. The reactions catalyzed by these complexes have been and will continue to be applied to the synthesis of polymers containing new properties, organic molecules with enhanced abilities to emit light, components of catalysts for other reactions, and organic probes for understanding biological systems. Work emanating from the proposed research is part of new curricula for the classroom, short-courses, many external lectures, and a major textbook project that will be completed in the next grant period by the PI.This research will lead to new methods to conduct chemical synthesis in fewer steps, with less waste, and with less reliance on the installation and protection of functional groups. In addition, this research creates the underlying principles on which future design of catalysts and processes for more efficient synthesis are based. Studies to define how the electronic properties of the metal and how electrophilic or nucleophilic properties of the reactive ligand affect C-H bond cleavage and functionalization will create these principles.

这项研究奖在无机，生物无机和有机化学计划支持教授约翰F。哈特维希在伊利诺伊大学厄巴纳-香槟分校开发反应，在典型的非反应性C-H键。 这项工作将创造新的方法，通过在对大多数试剂呈惰性的位置进行选择性化学转化来制备有机分子。 含有过渡金属和硼之间的键的络合物催化这些反应，并且该资助将揭示导致这种不寻常的反应性的过渡金属的性质。 这些配合物催化的反应已经并将继续应用于合成具有新性质的聚合物、具有增强发光能力的有机分子、用于其他反应的催化剂组分以及用于理解生物系统的有机探针。 从拟议的研究产生的工作是新课程的教室，短期课程，许多外部讲座，并将在下一个资助期完成的PI的主要教科书项目的一部分。这项研究将导致新的方法进行化学合成的步骤更少，废物更少，并与较少的依赖于安装和保护的功能组。 此外，这项研究创造了未来设计催化剂和更有效合成工艺的基本原则。 定义金属的电子性质以及反应性配体的亲电或亲核性质如何影响C-H键断裂和官能化的研究将创建这些原理。