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Implication of early embryonic epigenetic dysregulation in fetal alcohol spectrum disorders-associated outcomes

Implication of early embryonic epigenetic dysregulation in fetal alcohol spectrum disorders-associated outcomes
早期胚胎表观遗传失调对胎儿酒精谱系障碍相关结果的影响
批准号：
435858
负责人：
McGraw Serge
金额：
$60.19万
依托单位：
Centre hospitalier universitaire Sainte-Justine (Montral, Qubec)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2020
资助国家：
加拿大
项目状态：
未结题
起止时间：
2020-10-01 至 2025-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=435858&lang=en
关键词：
Adverse Maternal Exposure Brain Development Developmental Origin Of Health And Diseases (Dohad) Dna Methylation Epigenetics Fetal Alcohol Spectrum Disorders Fetal Development Gabaergic Interneurons Transcriptomics

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英文摘要
Fetal alcohol spectrum disorders (FASD), a widespread yet under-recognized condition found in all socioeconomic groups in Canada, results from maternal consumption of alcohol during pregnancy. The severity and presentation of FASD symptoms are highly vari
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Germline DNMT3A loss-of-function alters PRC2-dependent H3K27me3 deposition and leads to neuronal impairments.
Impact of early embryonic alcohol exposure on DNA methylation programming in the etiology of fetal alcohol spectrum disorders.
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