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Implication of early embryonic epigenetic dysregulation in fetal alcohol spectrum disorders-associated outcomes

Implication of early embryonic epigenetic dysregulation in fetal alcohol spectrum disorders-associated outcomes
早期胚胎表观遗传失调对胎儿酒精谱系障碍相关结果的影响
批准号：
435858
负责人：
McGraw Serge
金额：
$60.19万
依托单位：
Centre hospitalier universitaire Sainte-Justine (Montral, Qubec)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2020
资助国家：
加拿大
项目状态：
未结题
起止时间：
2020-10-01 至 2025-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=435858&lang=en
关键词：
Adverse Maternal Exposure Brain Development Developmental Origin Of Health And Diseases (Dohad) Dna Methylation Epigenetics Fetal Alcohol Spectrum Disorders Fetal Development Gabaergic Interneurons Transcriptomics

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中文摘要
翻译
胎儿酒精谱系障碍（FASD）是一种在加拿大所有社会经济群体中发现的普遍但未得到充分认识的疾病，是由于母亲在怀孕期间饮酒造成的。FASD症状的严重程度和表现形式是高度瓦里
英文摘要
Fetal alcohol spectrum disorders (FASD), a widespread yet under-recognized condition found in all socioeconomic groups in Canada, results from maternal consumption of alcohol during pregnancy. The severity and presentation of FASD symptoms are highly vari
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Germline DNMT3A loss-of-function alters PRC2-dependent H3K27me3 deposition and leads to neuronal impairments.
Impact of early embryonic alcohol exposure on DNA methylation programming in the etiology of fetal alcohol spectrum disorders.
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