课题基金 / 基金详情

Germline DNMT3A loss-of-function alters PRC2-dependent H3K27me3 deposition and leads to neuronal impairments.

Germline DNMT3A loss-of-function alters PRC2-dependent H3K27me3 deposition and leads to neuronal impairments.
种系 DNMT3A 功能丧失会改变 PRC2 依赖性 H3K27me3 沉积并导致神经元损伤。
批准号：
493576
负责人：
McGraw Serge
金额：
$7.29万
依托单位：
Centre hospitalier universitaire Sainte-Justine (Montral, Qubec)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
已结题
起止时间：
2023-09-01 至 2024-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=493576&lang=en
关键词：
Bioinformatics Brain Development Dna Methyltransferase 3a (Dnmt3a) Epigenetics Induced Pluripotent Stem Cells (Ipsc) Mouse Model Multiomic Approaches Polycomb Repressive Complex 2 (Prc2)

项目摘要

项目成果

McGraw Serge的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Tatton-Brown-Rahman Syndrome (TBRS) is a rare genetic disorder caused by loss-of-function mutations in the DNMT3A gene. Individuals with TBRS typically exhibit overgrowth, including tall stature, increased weight, and macrocephaly (large head circumferenc
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Implication of early embryonic epigenetic dysregulation in fetal alcohol spectrum disorders-associated outcomes
Impact of early embryonic alcohol exposure on DNA methylation programming in the etiology of fetal alcohol spectrum disorders.
海外基金