Japan JSPS Program: Synthesis of Vitamin D3 Metabolites and their Analogues

日本JSPS计划：维生素D3代谢物及其类似物的合成

• 批准号: 9505318
• 负责人: Salvador Alvarez
• 金额: $ 0.62万
• 依托单位: Individual Award
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 1996-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9505318&HistoricalAwards=false
• 关键词: Japan; JSPS; Program; Synthesis; Vitamin

This award supports a 12-month Japan Society for the Promotion of Science Postdoctoral Fellowship for Dr. Salvador G. Alvarez, Department of Chemistry, University of California, Santa Cruz. This fellowship opportunity will enable Dr. Alvarez to begin a collaborative research effort with Professor Isao Shimizu, Department of Applied Chemistry, Waseda University, Tokyo, Japan. The investigators propose a new method for the convergent asymmetric synthesis of 1-alpha, 25-dihydroxy-vitamin-D3 via the synthesis of the CD-ring fragment. This analogue of vitamin-D3 is an active steroid hormone and is a leading drug candidate for treating osteoporosis, a common disease with older populations. The proposed project provides a general synthesis of vitamin-D3 metabolites and their analogues for the exploration of structure activity relationship studies. This 12-month visit by Dr. Alvarez will provide him with a potential for future collaborative activities between the United States and Japan. As a postdoctoral fellow, Dr. Alvarez will have the opportunity to become familiar with novel research methodologies and steroid chemistry at Waseda University while contributing to the overall research effort. Therefore, this proposal fulfills the objectives of the program in its exchange and transfer of scientific knowledge through an international collaboration.

该奖项支持萨尔瓦多G博士为期12个月的日本科学促进会博士后奖学金。阿尔瓦雷斯，化学系，加州大学，圣克鲁斯。 这个奖学金机会将使阿尔瓦雷斯博士开始与日本东京早稻田大学应用化学系Isao Shimizu教授合作研究。 研究人员提出了一种新的方法，通过合成CD环片段来聚合不对称合成1-α，25-二羟基维生素-D3。 这种维生素D3的类似物是一种活性类固醇激素，是治疗骨质疏松症的主要候选药物，骨质疏松症是老年人的常见疾病。 本项目为维生素D3代谢物及其类似物的结构活性关系研究提供了一个通用的合成方法。阿尔瓦雷斯博士为期12个月的访问将为他提供美国和日本之间未来合作活动的潜力。作为博士后研究员，阿尔瓦雷斯博士将有机会熟悉早稻田大学的新研究方法和类固醇化学，同时为整体研究工作做出贡献。 因此，该提案通过国际合作实现了该计划在科学知识交流和转让方面的目标。