课题基金 / 基金详情

Thermodynamic and Molecular Mechanisms of Protein Stabilization by Polymers During Freezing, Drying, and Rehydration: EPR and FTIR Studies

Thermodynamic and Molecular Mechanisms of Protein Stabilization by Polymers During Freezing, Drying, and Rehydration: EPR and FTIR Studies
冷冻、干燥和再水合过程中聚合物稳定蛋白质的热力学和分子机制：EPR 和 FTIR 研究
批准号：
9505301
负责人：
Theodore Randolph
金额：
$39.87万
依托单位：
University of Colorado at Boulder
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1995
资助国家：
美国
项目状态：
已结题
起止时间：
1995-09-01 至 1998-08-31
来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9505301&HistoricalAwards=false
关键词：
ThermodynamicMolecularMechanismsProteinStabilization

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中文摘要
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英文摘要
9505301 Randolph This project is on research to better understand the mechanisms for polymer-induced protein stabilization in solution during freezing and drying. The research will focus on the thermodynamics and molecular interactions of polymeric additives with proteins in aqueous solutions, frozen solutions, and dried solids, and how these interactions dictate protein stability. In particular this includes: (1) solution thermodynamics which involves phase behavior and protein/polymer preferential interactions; and (2) experimental measurements which include differential scanning calorimetry, electron paramagnetic resonance spectroscopy (EPR) and resolution-enhanced Fourier transform infrared spectroscopy (FTIR). This will be used to determine why polymers work and why they fail as protein stabilizers. ***
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