International Postdoctoral Fellows Program: Antigene Strategies of Protein DNA Interfaces

国际博士后项目：蛋白质DNA界面的抗原策略

• 批准号: 9505345
• 负责人: David Perrin
• 金额: $ 3.85万
• 依托单位: Individual Award
• 依托单位国家: 美国
• 项目类别: Fixed Amount Award
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 1996-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9505345&HistoricalAwards=false
• 关键词: International; Postdoctoral; Fellows; Program; Antigene

9505345 Perrin The International Junior Investigator and Postdoctoral Fellows Program enables U.S. scientists and engineers to conduct three to twenty-four months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad. This award will support a twelve-month postdoctoral research visit by Dr. David M. Perrin to work with Professor Claude Helene of the Museum National d'Histoire Naturelle in France. Antisense technology encompasses virtually all research directed toward the rational generation of molecules which can associate with DNA and/or RNA to block protein production, suppress cell growth and division, or even kill the cell. The goal of this project is to characterize antisense interaction by exploring 1) the synthetic coupling of medicinally important DNA-damaging functionalities to the oligonucleotide, 2) the synthesis and properties of more resilient nucleotides, 3) the synthetic coupling of intercalators to increase the stability of the interaction and to characterize the antisense association by spectrophotometric techniques and 4)the generation of other sequences whose inhibitory properties will be examined in- vivo in bacterial and mammalian cell systems. ***

小行星9505345 国际初级研究员和博士后研究员计划使美国科学家和工程师能够在国外进行三到二十四个月的研究。该计划的奖项提供了联合研究的机会，以及使用国外独特或互补的设施，专业知识和实验条件。 该奖项将支持为期12个月的博士后研究访问博士大卫M。佩兰与法国国家自然历史博物馆的克劳德·海琳教授合作。 反义技术几乎涵盖了所有针对合理产生分子的研究，这些分子可以与DNA和/或RNA结合以阻断蛋白质产生，抑制细胞生长和分裂，甚至杀死细胞。 该项目的目标是通过探索1）医学上重要的DNA损伤功能与寡核苷酸的合成偶联，2）更具弹性的核苷酸的合成和性质，3）嵌入剂的合成偶联以增加相互作用的稳定性并通过分光光度技术表征反义缔合，以及4）在细菌和哺乳动物细胞系统中体内检测其抑制特性的其它序列的产生。***