International Postdoctoral Fellows Program: Synthesis of Carbon-11 Labeled Steroidal Androgen Receptor Ligands

小行星9505394 国际初级研究员和博士后研究员计划使美国科学家和工程师能够在国外进行三到二十四个月的研究。该计划的奖项提供了联合研究的机会，以及使用国外独特或互补的设施，专业知识和实验条件。 该奖项将为托马斯A博士的博士后研究访问提供部分支持。Bonasera将与瑞典乌普萨拉大学PET中心的Bengt罗兰Langstrom教授合作。 最初十个月的研究将由富布赖特基金资助。 这个奖项将允许Bonasera博士做一整年的研究。 本研究项目的目的是研究放射化学合成的碳-11标记的甾体雄激素受体配体作为潜在的成像剂的正电子发射断层扫描（PET）评估男性前列腺癌的雄激素受体蛋白。 几种雄激素受体配体（对雄激素受体蛋白具有高亲和力的类固醇）将以碳-11标记的形式合成。 其中一些将在两个不同的位置用碳11标记。 主要目的是开发有效的反应条件的碳-11放射性标记的这些类固醇，以优化反应产率在每个步骤的合成，并选择一个或多个配体作为PET显像剂的进一步研究。***

9505394 Bonasera The International Junior Investigator and Postdoctoral Fellows Program enables U.S. scientists and engineers to conduct three to twenty-four months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad. This award will provide partial support for a postdoctoral research visit by Dr. Thomas A. Bonasera to work with Professor Bengt Roland Langstrom of Uppsala University PET Centre in Sweden. The initial ten months of research will be supported by a Fulbright grant. This award will allow Dr. Bonasera to do a full year of research. The purpose of this research project is to study the radiochemical synthesis of carbon-11 labeled steroidal androgen receptor ligands as potential imaging agents for positron emission tomographic (PET) assessment of the androgen receptor protein in men with prostate cancer. Several androgen receptor ligands (steroids with high affinity for the androgen receptor protein) will be synthesized in the carbon-11 labeled form. Some of them will be labeled at two different positions with carbon-11. The main objective is to develop efficient reaction conditions for the carbon-11 radiolabeling of these steroids, to optimize the reaction yields in each step of the synthesis, and to select one or more of the ligands for further future study as a PET imaging agent. ***