International Postdoctoral Fellows Program: Synthesis of Carbon-11 Labeled Steroidal Androgen Receptor Ligands

Bonasera国际青年研究员和博士后研究员计划使美国科学家和工程师能够在国外进行三到二十四个月的研究。该计划的奖励为联合研究提供了机会，并利用独特或互补的设施、专业知识和国外的实验条件。该奖项将为Thomas a . Bonasera博士与瑞典乌普萨拉大学PET中心的Bengt Roland Langstrom教授的博士后研究访问提供部分支持。最初十个月的研究将由富布赖特基金资助。这笔奖金将允许Bonasera博士进行一整年的研究。本研究的目的是研究碳-11标记的甾体雄激素受体配体的放射化学合成，作为前列腺癌男性雄激素受体蛋白正电子发射断层扫描（PET）评估的潜在显像剂。几种雄激素受体配体（对雄激素受体蛋白具有高亲和力的类固醇）将以碳-11标记的形式合成。其中一些会在两个不同的位置被碳-11标记。主要目的是为这些类固醇的碳-11放射性标记开发有效的反应条件，优化合成每一步的反应产率，并选择一种或多种配体作为PET显像剂进行进一步的研究。* * *

9505394 Bonasera The International Junior Investigator and Postdoctoral Fellows Program enables U.S. scientists and engineers to conduct three to twenty-four months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad. This award will provide partial support for a postdoctoral research visit by Dr. Thomas A. Bonasera to work with Professor Bengt Roland Langstrom of Uppsala University PET Centre in Sweden. The initial ten months of research will be supported by a Fulbright grant. This award will allow Dr. Bonasera to do a full year of research. The purpose of this research project is to study the radiochemical synthesis of carbon-11 labeled steroidal androgen receptor ligands as potential imaging agents for positron emission tomographic (PET) assessment of the androgen receptor protein in men with prostate cancer. Several androgen receptor ligands (steroids with high affinity for the androgen receptor protein) will be synthesized in the carbon-11 labeled form. Some of them will be labeled at two different positions with carbon-11. The main objective is to develop efficient reaction conditions for the carbon-11 radiolabeling of these steroids, to optimize the reaction yields in each step of the synthesis, and to select one or more of the ligands for further future study as a PET imaging agent. ***