Poly-3-Hydroxybutyrate/Polyphosphate Ion Channels
聚 3-羟基丁酸/聚磷酸盐离子通道
基本信息
- 批准号:9507282
- 负责人:
- 金额:$ 23.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1995
- 资助国家:美国
- 起止时间:1995-08-01 至 1999-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
; R o o t E n t r y F o9 C o m p O b j b W o r d D o c u m e n t O b j e c t P o o l o9 o9 4 @ + , - . / 0 1 2 3 4 5 F Microsoft Word 6.0 Document MSWordDoc Word.Document.6 ; Abstract 9507282 Reusch Polyhydroxybutyrate and polyphosphate are polymers found in all biological cells, yet their functions are largely unknown. This investigator has isolated an ion channel from bacterial membranes which is composed of polyhydroxybutyrate and polyphosphate. The polymers combine to form a calcium-selective ion channel with many of the same properties as the protein calcium channels found in plant and animal cell membranes. The capacity of polyhydroxybutryate and polyphosphate to form ion channels derives from the ability of the polyhydroxybutryate to dissolve salts, and that of polyphosphate to bind some cations more strongly than others. The ion-selective properties of polyphosphates have led to their use in water-softening, and the solvent properties of polyhydroxybutyrate are very similar to those of the polyethers used in lithium batteries, suggesting that polyhydroxybutryate can be used to prepare ion-conducting materials. In this research the effects of temperature, pH and salts on the conductance and selectivity of the polyhydroxybutryate/polyphosphate ion channel s extracted from E. coli as well as complexes reconstituted from their components uill be determined. These complexes will be incorporated into planar lipid bilayers and studied with voltage clamp techniques. Computer molecular mechanics and molecular dynamics computations will determine the most likely conformations of the polymers in the channel complexes and elucidate blocking mechanisms. %%% These studies on these polymers in channel complexes will provide new insights into the mechanisms of ion-conduction in biological ion channels and bulk phase polymer electrolytes, and suggest new applications in material science. *** ; Oh +' 0 $ H l D h R:\WWUSER\TEMPLATE\NORMAL.DOT Abstract Barbara Zain Barbara Zain @ q S u m m a r y I n f o r m a t i o n ( * 1 @ @ ıo9 @ F # Microsoft Word 6.0 2 ; e = e l l l l l l l D 1 # & u T 4 D l D l l l l l l l l 7 Abstract 9507282 Reusch Polyhydroxybutyrate and polyphosphate are polymers found in all biological cells, yet their functions are largely unknown. This investigator has isolated an ion channel from bacterial membranes which is composed of polyhydroxybutyrate and polyphosphate. The polymers combine to form a calcium-selective ion channel with many of the same properties as the protein calcium channels found in plant and animal cell membranes. The capacity of polyhydroxybutryate and polyphosphate to form ion channels derives from the ability of the polyhydroxybutryate to dissolve salts, and that of polyphosphate to bind some cations more strongly than others. The ion-selective properties of polyphosphates have led to their use in water-softening, and the solvent properties of polyhydroxybutyrate are very similar to those of the polyethers used in lithium batteries, suggesting that polyhydroxybutryate can be used to prepare ion-conducting materials. In this research the effects of temperature, pH and salts on the conductance and selectivity of the polyhydroxybut
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rosetta Reusch其他文献
Rosetta Reusch的其他文献
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{{ truncateString('Rosetta Reusch', 18)}}的其他基金
Polyhydroxybutyrate/Polyphosphate Complexes as Conductive Cores of Ion Channels
聚羟基丁酸酯/聚磷酸盐复合物作为离子通道的导电核心
- 批准号:
0445067 - 财政年份:2005
- 资助金额:
$ 23.59万 - 项目类别:
Continuing Grant
Polyhydroxybutyrate/Polyphosphate Complexes as Conductive Cores of Ion Channels
聚羟基丁酸酯/聚磷酸盐复合物作为离子通道的导电核心
- 批准号:
0422938 - 财政年份:2004
- 资助金额:
$ 23.59万 - 项目类别:
Standard Grant
Poly (3-Hydroxybutyrate)/Polyphosphate Ion Channels
聚(3-羟基丁酸)/聚磷酸盐离子通道
- 批准号:
9816053 - 财政年份:1999
- 资助金额:
$ 23.59万 - 项目类别:
Continuing Grant
Conductance of Poly-3-hydroxybutyrate/calcium Polyphosphate Complexes in Planar Bilayers
平面双层中聚 3-羟基丁酸酯/聚磷酸钙复合物的电导
- 批准号:
9209364 - 财政年份:1992
- 资助金额:
$ 23.59万 - 项目类别:
Standard Grant
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