Polymer Solutions, Coil-Globule and Other Phase Transitions, US-Turkey Cooperative Research

聚合物溶液、线圈球体和其他相变，美国-土耳其合作研究

• 批准号: 9507751
• 负责人: Frank Karasz
• 金额: $ 4.33万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-15 至 1998-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9507751&HistoricalAwards=false
• 关键词: Polymer; Solutions; Coil; Globule; Other

Description: This project supports collaboration by Dr. Frank Karasz, Professor of Polymer Science and Engineering at the University of Massachusetts, and two Turkish scientists: Dr. Bahattin Baysal, Director, Research Institute of Basic Sciences at the Marmara Research Centre (MRC), Gebze, Turkey and Dr. E. Elif Hamurcu, a Reserach Assistant at Bogazici University in Istanbul and also a Research Specialist in the Polymer Research Project at the MRC. The research deals with the transition of a polymer chain in dilute solution from an expanded coil in a good solvent to a collapsed, compact globular structure in a poor solvent. A comprehensive and quantitative understanding of chain collapse has not yet been achieved through experimental or theoretical means. The phenomena is intimately related to certain biological processes, including DNA folding and protein denaturation and tertiary structure formation. In this project the two scientists will use experimental techniques, including dynamic light scattering and viscometry, in detailed studies of coil collapse in near theta conditions for polar macromolecules in binary and ternary systems. Volume-phase transitions in network systems will also be investigated. Scope: This project brings together two scientists with excellent experiences and strong capabilities in research in the field of polymers. Dr. Karasz has investigated the helix-coil transition of polypeptides with calorimetric and scattering methods, and the conformational variation of linear and star, flexible and semiflexible macromolecules in solution as functions of molecular weight, concentration, architecture, ionic strength and confining geometry. Dr. Baysal has studied chain characteristics in dilute solution including coil-to-globule transition with theoretical analysis and viscometric and dielectric experiments. These complementary expertise provide for a logical combination of their research interests. A postdoctorate from MRC also will participate in the research at the U. of Massachusetts. The project meets the objectives of the Division of International Programs.

描述：该项目支持马萨诸塞大学聚合物科学与工程教授Frank Karasz博士与两名土耳其科学家的合作：土耳其格布兹马尔马拉研究中心(MRC)基础科学研究所所长Bahattin Baysal博士和伊斯坦布尔Bogazici大学研究助理、MRC聚合物研究项目研究专家E.Elif Hamurcu博士。这项研究涉及聚合物链在稀溶液中的转变，从在良好溶剂中的膨胀卷曲到在不良溶剂中折叠的致密球状结构。通过实验或理论手段，还没有达到对链崩溃的全面和定量的理解。这些现象与某些生物过程密切相关，包括DNA折叠、蛋白质变性和三级结构形成。在这个项目中，两位科学家将使用包括动态光散射和粘度学在内的实验技术，详细研究二元系和三元系中极性大分子在接近theta的条件下卷曲崩溃的情况。还将研究网络系统中的体积-相变。范围：该项目汇集了两位在聚合物领域拥有出色经验和强大研究能力的科学家。Karasz博士用量热法和散射法研究了多肽的螺旋-螺旋转变，以及线形和星形、柔性和半柔性大分子在溶液中的构象随分子量、浓度、结构、离子强度和限制几何形状的变化。贝萨尔博士通过理论分析以及粘度学和介电学实验研究了稀溶液中的链特征，包括从线圈到球状的转变。这些互补的专业知识为他们的研究兴趣提供了一个合理的组合。麻省理工学院的博士后也将参与马萨诸塞大学的研究。该项目符合国际方案司的目标。