RPG: Mitochondrial Metabolic Properties of Endothermic and Ectothermic Vertebrates

RPG：吸热和变热脊椎动物的线粒体代谢特性

• 批准号: 9508628
• 负责人: Nancy Berner
• 金额: $ 1.8万
• 依托单位: University of the South
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-15 至 1997-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9508628&HistoricalAwards=false
• 关键词: RPG; Mitochondrial; Metabolic; Properties; Endothermic

9508628 Berner Organisms generate heat by the breakdown of fuels during cellular metabolism. In endotherms, metabolic heat can be produced fast enough to raise body temperature significantly above that of the surroundings. In ectotherms, rates of metabolic heat production are so low that body temperature is determined primarily by the surrounding environment. The aim of this research is to determine the mechanisms that permit endotherms to produce heat at a greater rate than can ectotherms. High rates of metabolic heat production are usually linked to high rates of oxygen consumption and production of usable chemical potential energy. These last two processes occur in subcellular organelles, the mitochondria. This research will contrast the rate of oxygen consumption and chemical potential energy (ATP) production by the mitochondria of endotherms and ectotherms under a variety of conditions. Experimental treatments will include varying the temperature at which the mitochondria work and varying the fuels provided to the mitochondria as they perform their metabolic functions. The research will improve understanding of the mechanisms responsible for metabolic differences between endotherms and ectotherms and of how these differences evolved.

9508628 伯纳生物体通过细胞新陈代谢过程中燃料的分解产生热量。 在吸热动物中，代谢热的产生速度足以使体温明显高于周围环境。 在变温动物中，代谢产热率非常低，以至于体温主要由周围环境决定。 这项研究的目的是确定吸热动物比变温动物以更高的速率产生热量的机制。 高代谢热产生率通常与高耗氧率和可用化学势能的产生有关。 最后两个过程发生在亚细胞细胞器线粒体中。 这项研究将比较吸温动物和变温动物的线粒体在各种条件下的耗氧率和化学势能 (ATP) 产生率。 实验治疗将包括改变线粒体工作的温度以及改变线粒体执行代谢功能时提供给线粒体的燃料。 该研究将增进对吸温动物和变温动物之间代谢差异的机制以及这些差异如何进化的理解。