Molecular Population Genetics of Drosophila

兰利9509548 这项研究的目标是定量了解决定分子遗传变异和物种之间的分歧的力量。 对突变、重组、自然选择和遗传漂变的影响的这种理解是农业、保护和医学遗传学有效应用的基础。 第一个项目是对四个黑腹果蝇种群中靠近X染色体顶端的四个基因的DNA序列变异进行彻底和定量的调查。 几个目前可行的假说试图解释在这些基因组区域中持续观察到的杂合性减少。 这些模型将用本次调查的数据进行检验。 实验二是在D.这将提供一个“复制”，并允许变异和分歧之间的关系进行仔细分析。

9509548 LANGLEY The goal of this research is a quantitative understanding of the forces determining molecular genetic variation and divergence between species. Such understanding of the effects of mutation, recombination, natural selection and genetic drift is fundamental to effective applications in agricultural, conservation and medical genetics. The first project is a thorough and quantitative survey of DNA sequence variation at four genes near the tip of the X chromosome (where crossing over is much reduced) in four populations of Drosophila melanogaster. Several currently viable hypotheses attempt to explain the consistently observed reduction of heterozygosity in these regions of the genome. These models will be tested with the data from this survey. The second experiment is a parallel survey in D. simulans that will provide a "replication" and allow a careful analysis of the relationship between variation and divergence.