Acquisition of Instrumentation for an Oklahoma Statewide Shared NMR Facility

为俄克拉荷马州全州共享核磁共振设施购买仪器

• 批准号: 9512269
• 负责人: Warren Ford
• 金额: $ 73.5万
• 依托单位: Oklahoma State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-15 至 1998-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9512269&HistoricalAwards=false
• 关键词: Acquisition; Instrumentation; Oklahoma; Statewide; Shared

Support is requested for the purchase of a 600 MHz NMR spectrometer to be housed in the Department of Chemistry at Oklahoma State University, for an upgrade of an on-site 400 MHz instrument, and for data stations to link students and researchers at institutions all over the State of Oklahoma to the NMR Facility. The key to statewide use of the facility is communication via the Oklahoma ONENET, a 45 Mb/sec Ethernet system that links Oklahoma State University (Stillwater), the Oklahoma Health Sciences Center (Oklahoma City), and the University of Oklahoma (Norman). The data stations at the research universities will be used for remote control of the 600 MHz spectrometer, off-line data analysis of multidimensional spectra from the 600 MHz instrument, and off-site instruction of research associates and graduate students in modern NMR spectroscopy. The Oklahoma ONENET has 1 Mb/sec service to link the NMR facility to data stations at 6 regional universities for the education of undergraduate science majors in modern NMR spectroscopy and for analysis of spectra from the 400 MHz instrument. A state-of-the-art 300 MHz NMR spectrometer dedicated to the study of solid state materials and installed at OSU in 1993 will also become part of the statewide NMR Facility. The centerpiece of the proposed Facility is a 600 MHz NMR spectrometer to be used by researchers at the Oklahoma Health Sciences Center (OHSC), University of Oklahoma (OU), and Oklahoma State University (OSU) for the study of glycopeptides, derivatives of ubiquinone bound to proteins, structures of paramagnetic proteins, microstructures of synthetic polymers, components of primary plant cell walls, and organic natural products from marine sources. For this research, high spectrometer frequency is needed to disperse spectral signals that overlap at lower frequencies. The proposed 3-channel 600 MHz spectrometer will be equipped with pulsed field gradient (PFG) and waveform generation capabilities required for state-of -the-art NMR experiments, and with probes ranging from a microprobe for study of submicromole amounts of natural materials to a 10 mm probe with an enhanced shim set for study of proteins of limited solubility. The 400 MHz NMR spectrometer at OSU, which was installed in 1988, will be upgraded to a 3-channel unit and have many of the same capabilities as the 600 MHz unit: pulsed field gradients, waveform generation, direct and indirect probes. It will be used for experiments that do not require the 600 MHz spectrometer and for preliminary experiments on certain samples that may later require the 600 MHz spectrometer. Policies of the Facility will be established by a statewide committee of users and administered by an OSU Faculty Director. Daily operation of the Facility will be the respmnsibility of the Facility Manager, a full time Ph.D. spectroscopist with responsibilities to assist and train users in the design, execution, and interpretation of experiments. An electronics technician dedicated full time to the Facility will maintain the equipment. Linkage of the Facility spectrometers at OSU to the research centers at OU and OHSC and to the regional universities in Oklahoma via the Oklahoma ONENET will provide both rapid communication between the NMR facility and off-site users and the mechanism for instruction of students at all levels by the Facility Manager and OSU faculty in modern NMR spectroscopy. OSU is a leader in providing instruction via telecommunication. Thus the project will both markedly enhance research capabilities for determination of structures of natural and synthetic macromolecules at three research universities, and expand education in modern NMR spectroscopy to more than 85% of the undergraduate students majoring in chemistry and biochemistry in Oklahoma. The office of the Oklahoma State Regents for Higher Education envisions the proposed Olclahoma Statewide Shared NMR Facility evolving into a distributive facility with major NMR inst ruments at various sites in Oklahoma all connected by Internet to scientists throughout the state.

请求提供支助，用于购买一台600兆赫核磁共振波谱仪，供俄克拉荷马州州立大学化学系使用，用于升级一台现场400兆赫仪器，并用于建立数据站，将俄克拉荷马州各地各机构的学生和研究人员与核磁共振设施连接起来。全州范围内使用该设施的关键是通过俄克拉荷马州ONENET进行通信，ONENET是一个45 Mb/秒的以太网系统，连接俄克拉荷马州州立大学（斯蒂尔沃特）、俄克拉荷马州健康科学中心（俄克拉荷马州城）和大学。俄克拉荷马州（诺曼）。研究型大学的数据站将用于远程控制600兆赫光谱仪，对600兆赫仪器的多维光谱进行离线数据分析，以及对研究人员和研究生进行现代核磁共振光谱学的非现场指导。俄克拉荷马州的ONENET具有1 Mb/sec的服务，将NMR设施与6所地区大学的数据站连接起来，用于现代NMR光谱学本科理科专业的教育和400 MHz仪器的光谱分析。一个国家的最先进的300兆赫核磁共振光谱仪致力于研究固态材料和安装在俄勒冈州立大学于1993年也将成为全州核磁共振设施的一部分。 拟议设施的核心是一个600 MHz NMR光谱仪，供俄克拉荷马州健康科学中心（OHSC）、俄克拉荷马州大学（OSC）和俄克拉荷马州州立大学（OSU）的研究人员使用，用于研究糖肽、与蛋白质结合的泛醌衍生物、顺磁性蛋白质的结构、合成聚合物的微观结构、初级植物细胞壁的组分、和海洋来源的有机天然产品。对于这项研究，需要高光谱仪频率来分散在较低频率处重叠的光谱信号。拟议的3通道600 MHz光谱仪将配备脉冲场梯度（PFG）和波形生成能力所需的国家的最先进的NMR实验，并与探针范围从一个微探针的研究submicromole量的天然材料，以10毫米的探针与增强的垫片集研究有限的溶解度的蛋白质。 俄勒冈州立大学于1988年安装的400 MHz核磁共振波谱仪将升级为3通道装置，并具有许多与600 MHz装置相同的功能：脉冲场梯度、波形生成、直接和间接探头。它将用于不需要600 MHz光谱仪的实验，以及对某些样品的初步实验，这些样品以后可能需要600 MHz光谱仪。 该设施的政策将由全州范围的用户委员会建立，并由俄勒冈州立大学学院院长管理。设施的日常运营将由设施经理负责，设施经理是一名全职博士。光谱学家，负责协助和培训用户设计、执行和解释实验。一名专职于该设施的电子技术员将维护该设备。 通过俄克拉荷马州ONENET，将OSU的设备光谱仪连接到OMSC和OHSC的研究中心以及俄克拉荷马州的地区大学，将提供NMR设备和场外用户之间的快速通信，并提供设备经理和OSU教师在现代NMR光谱学方面对各级学生进行指导的机制。俄勒冈州立大学是通过电信提供教学的领导者。因此，该项目将显著提高三所研究型大学确定天然和合成大分子结构的研究能力，并将现代NMR光谱学的教育扩大到俄克拉荷马州85%以上的化学和生物化学专业的本科生。 俄克拉荷马州高等教育委员会办公室设想，拟议中的俄克拉荷马州全州共享NMR设施将发展成为一个分布式设施，俄克拉荷马州各个地点的主要NMR仪器都通过互联网与全州的科学家相连。