The Comparative Experimental Embryology of Brachiopods

腕足动物比较实验胚胎学

基本信息

  • 批准号:
    9513068
  • 负责人:
  • 金额:
    $ 28.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    1996
  • 资助国家:
    美国
  • 起止时间:
    1996-01-01 至 1999-12-31
  • 项目状态:
    已结题

项目摘要

9513068 Freeman One goal of the field of developmental biology is to understand how and why the utilization of the mechanisms responsible for the spatial organization of multicellular organisms changes during the course of evolution. This proposal will study this problem in the Phoronida and the related phylum, Brachiopoda. The Phoronida are unknown as fossils; however, because of their shell, brachiopods have an excellent fossil record which has allowed paleontologists to do a rather convincing job of reconstructing the history of this phylum. A number of extant brachiopod species are derived from, and closely resemble, ancestors that represent important nodes in this phylogeny. Experimental studies will be performed on the embryos of these species in order to establish when, during development, different parts of the embryo become specified and to identify the mechanisms that are responsible for regional specification. These experiments begin with the construction of a fate map for each embryo indicating the regions of hte larva that develop from specific parts of the egg and early embryo. Then diffenrent regions of the embryo will be isolated at various stages of development, and their ability to differentiate will be compared to that of the same region in a whole embryo as indicated by the fate map. By isolating parts of eggs and embryos in combination with other parts and at different developmental stages, one can infer whether the development of a given region is autonomous or conditional. By comparing the timing and mode of regional specification during embryogenesis for a series of species at different nodes in the phyylogeny, one can document the changes in the utilization of mechanisms for regional specification that accompany evolutionary change. Some of these species have larvae that are morphologically similar and have similar life histories although these species are not closely related, while other species are closely related but have very different larvae with different life history strategies. Comparisons beteen these species will allow one to dissect out the role of larval evolution versus the evolution of adult structures in bringing about developmental changes involving early embryogenesis. ***
小行星9513068 发育生物学领域的一个目标是了解在进化过程中,负责多细胞生物空间组织的机制如何以及为什么会发生变化。这个建议将研究这个问题在Phoronida和相关的门,腕足动物。Phoronida作为化石是未知的;然而,由于它们的外壳,腕足动物有一个很好的化石记录,这使得古生物学家能够做一个相当令人信服的工作来重建这个门的历史。一些现存的腕足类物种来自,并非常相似,祖先代表了这一进化史中的重要节点。将对这些物种的胚胎进行实验研究,以确定在发育过程中胚胎的不同部分何时变得特定,并确定负责区域特定的机制。这些实验开始,为每个胚胎构建一个命运图,指示从卵和早期胚胎的特定部分发育的幼虫的区域。然后,将胚胎的不同区域在不同的发育阶段分离,并将它们的分化能力与整个胚胎中相同区域的分化能力进行比较,如命运图所示。通过将卵子和胚胎的部分与其他部分结合并在不同的发育阶段分离,人们可以推断给定区域的发育是自主的还是有条件的。通过比较胚胎发育过程中的一系列物种在不同的节点在phyylogeny的时间和模式的区域规格,可以记录的变化,利用机制的区域规格,伴随着进化的变化。其中一些物种的幼虫形态相似,具有相似的生活史,尽管这些物种并不密切相关,而其他物种密切相关,但具有非常不同的幼虫,具有不同的生活史策略。这些物种之间的比较将允许一个解剖出的作用,幼虫的进化与成人结构的进化,在带来发育变化,涉及早期胚胎发生。 ***

项目成果

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Gary Freeman其他文献

Retrospective evaluation of current-based impedance compensation defibrillation in out-of-hospital cardiac arrest
基于电流的阻抗补偿除颤在院外心脏骤停中的回顾性评估
  • DOI:
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    6.5
  • 作者:
    Bihua Chen;Changlin Yin;Giuseppe Ristagno;Weilun Quan;Qing Tan;Gary Freeman;Yongqin Li
  • 通讯作者:
    Yongqin Li
The Plumbago North pegmatite, Maine, USA: a new potential lithium resource
美国缅因州 Plumbago North 伟晶岩:新的潜在锂资源
  • DOI:
    10.1007/s00126-020-00956-y
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    W. Simmons;A. Falster;Gary Freeman
  • 通讯作者:
    Gary Freeman
AS21 Significant decreases in amplitude spectrumarea during pre-defibrillation pauses in chest compression in out-of-hospital cardiac arrest patients
  • DOI:
    10.1016/s0300-9572(11)70022-3
  • 发表时间:
    2011-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Giuseppe Ristagno;Weilun Quan;Qing Tan;Frederick Geheb;Gary Freeman;Wanchun Tang
  • 通讯作者:
    Wanchun Tang
Homogenous and heterogeneous site outcomes from an international resuscitation trial
  • DOI:
    10.1016/j.resuscitation.2006.06.136
  • 发表时间:
    2006-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    James Palazzolo;James Brewer;Gary Freeman;Henry Halperin
  • 通讯作者:
    Henry Halperin
AP023 Improved accuracy of prediction of defibrillation success by shortening amplitude spectrum area integration intervals in out-of-hospital cardiac arrest
  • DOI:
    10.1016/s0300-9572(11)70057-0
  • 发表时间:
    2011-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Weilun Quan;Frederick Geheb;Gary Freeman;Joe Bisera
  • 通讯作者:
    Joe Bisera

Gary Freeman的其他文献

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{{ truncateString('Gary Freeman', 18)}}的其他基金

The Developmental Basis for Evolutionary Changes in the Larval Biology of Brachiopods
腕足动物幼虫生物学进化变化的发育基础
  • 批准号:
    9982025
  • 财政年份:
    2000
  • 资助金额:
    $ 28.18万
  • 项目类别:
    Continuing Grant
Collaborative Project: Calcium in the Early Development of Hydrozoan
合作项目:水螅虫早期发育中的钙
  • 批准号:
    9207441
  • 财政年份:
    1992
  • 资助金额:
    $ 28.18万
  • 项目类别:
    Standard Grant
Collaborative Project: Calcium in the Early Development of Hydrozoans
合作项目:水螅动物早期发育中的钙
  • 批准号:
    8904333
  • 财政年份:
    1989
  • 资助金额:
    $ 28.18万
  • 项目类别:
    Continuing Grant
The Role of Animal-Vegetal Axial Properties in Integrating Echinoid Development: A Long-Term Cooperative Research Visit to Japan
动植物轴向特性在海胆发育整合中的作用:对日本的长期合作研究访问
  • 批准号:
    8410353
  • 财政年份:
    1985
  • 资助金额:
    $ 28.18万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research in Political Science
政治学博士论文研究
  • 批准号:
    7724969
  • 财政年份:
    1978
  • 资助金额:
    $ 28.18万
  • 项目类别:
    Standard Grant

相似海外基金

Combining experimental embryology and geometric morphometrics to uncover the evolution of vertebral variability in Lake Malawi cichlids
结合实验胚胎学和几何形态测量学来揭示马拉维湖慈鲷脊椎变异的进化
  • 批准号:
    2445747
  • 财政年份:
    2020
  • 资助金额:
    $ 28.18万
  • 项目类别:
    Studentship
Paul Klee and experimental embryology
保罗·克利和实验胚胎学
  • 批准号:
    23520134
  • 财政年份:
    2011
  • 资助金额:
    $ 28.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
SBIR Phase I: Comparative and Experimental Embryology Multimedia Software
SBIR 第一阶段:比较和实验胚胎学多媒体软件
  • 批准号:
    9760800
  • 财政年份:
    1998
  • 资助金额:
    $ 28.18万
  • 项目类别:
    Standard Grant
CORE--IN VITRO FERTILIZATION AND EXPERIMENTAL EMBRYOLOGY
核心——体外受精和实验胚胎学
  • 批准号:
    6258768
  • 财政年份:
    1998
  • 资助金额:
    $ 28.18万
  • 项目类别:
PRIMATE EXPERIMENTAL EMBRYOLOGY ISOLATION OF ES CELLS & INTERSPECIFIC CHIMERAS
ES 细胞的灵长类实验胚胎学分离
  • 批准号:
    6247602
  • 财政年份:
    1997
  • 资助金额:
    $ 28.18万
  • 项目类别:
CORE--IN VITRO FERTILIZATION AND EXPERIMENTAL EMBRYOLOGY
核心——体外受精和实验胚胎学
  • 批准号:
    6240944
  • 财政年份:
    1997
  • 资助金额:
    $ 28.18万
  • 项目类别:
Experimental study of the embryology in the ear
耳胚胎学的实验研究
  • 批准号:
    60480380
  • 财政年份:
    1985
  • 资助金额:
    $ 28.18万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
The Emergence and Acceptance of American Experimental Embryology
美国实验胚胎学的出现和接受
  • 批准号:
    7912542
  • 财政年份:
    1979
  • 资助金额:
    $ 28.18万
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    Standard Grant
GRADUATE RESEARCH PROGRAM IN EXPERIMENTAL EMBRYOLOGY
实验胚胎学研究生研究项目
  • 批准号:
    71Z1912
  • 财政年份:
    1971
  • 资助金额:
    $ 28.18万
  • 项目类别:
Graduate Research Program in Experimental Embryology
实验胚胎学研究生研究计划
  • 批准号:
    7104455
  • 财政年份:
    1971
  • 资助金额:
    $ 28.18万
  • 项目类别:
    Standard Grant
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