CAREER: Steroid-Mimicking Properties of Xenobiotics: Mechanisms of Action and their Role in Amphibian Declines

职业：异生素的类固醇模拟特性：作用机制及其在两栖动物衰退中的作用

• 批准号: 9513362
• 负责人: Tyrone Hayes
• 金额: $ 54.94万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9513362&HistoricalAwards=false
• 关键词: CAREER; Steroid; Mimicking; Properties; Xenobiotics

9513362 Hayes The ultimate goal of this study is to assess and define the potential role of pollutants and pesticides such as DDT on the rapid disappearance of amphibians worldwide, particularly frogs. Many of these pollutants act on the frogs as the animal's own substances do. Consequently, a deeper understanding of the physiologic molecules and mechanisms may ultimately shed light on not only basic survival mechanisms but also disruptive mechanisms which are at the core of the decline of these species. Another significant thrust of this project is to involve students, both undergraduate and graduate, in various stages of the project, thereby allowing them not only to develop as future scientists but also to acquire an awareness of this significant disruption of biological life. ***

这项研究的最终目标是评估和确定污染物和杀虫剂（如滴滴涕）在全球两栖动物（特别是青蛙）迅速消失中的潜在作用。这些污染物中的许多对青蛙的作用就像动物自身的物质一样。因此，对生理分子和机制的更深入了解不仅可以揭示基本的生存机制，还可以揭示这些物种衰退的核心破坏机制。这个项目的另一个重要推力是让本科生和研究生参与项目的各个阶段，从而使他们不仅能够发展成为未来的科学家，而且能够了解这种对生物生命的重大破坏。＊＊＊