DISSERTATION RESEARCH: Interpopulation Crosses: A Molecular Genetic Analysis of Selection

摘要在种群间存在遗传差异的物种中，跨种群交配可能会降低繁殖成功率。多次交配可以通过允许雌性筛选基因不相容的配子来提供有效的防御。这项研究将使用一个物种来测试这一假设，在这个物种中，谱系分析和单位点、小卫星DNA指纹已经检测到减数分裂驱动和女性偏向的性别比例。这些现象与小鼠和果蝇的雌性繁殖成功率降低有关。这一假设将通过调查已经分化到部分生殖不相容的种群之间杂交的生殖后果来检验。将具有分离扭曲和/或性别比例扭曲能力的等位基因与对这些等位基因缺乏共同进化不敏感的应答位点结合在一起的杂交可能产生这种不亲和性。单位点DNA指纹图谱将确定杂种中是否释放了抑制的基因组内冲突或核胞质冲突。它将检验这样一种预测，即多次交配使雌性能够通过将资源分流到可存活的胚胎上，或通过隐秘地选择基因相容的精子，来保护自己的生殖投资。

Strassmann 9520861 Abstract In species where genetic divergence between populations has occurred, mating across population boundaries may reduce reproductive success. Multiple mating may provide an effective defense against by permitting females to screen out genetically incompatible gametes. This research will test that hypothesis using a species in which pedigree analysis and single locus, minisatellite DNA fingerprinting have detected meiotic drive and female-biased sex ratios. These phenomena are linked to reduced female reproductive success in mice and Drosophila. The hypothesis will be tested by investigation of the reproductive consequences of crosses between populations that have diverged to the point of partial reproductive incompatibility. Hybrids that combine alleles capable of segregation distortion and/or skewing of sex ratios with responder loci lacking coevolved insensitivity to such alleles may produce such incompatibility. Single-locus DNA fingerprinting will determine whether suppressed intragenomic or nucleo cytoplasmic conflict is unleashed in hybrids. It will test the prediction that multiple mating enables females to safeguard their reproductive investment either by shunting resources to viable embryos, or through cryptic choice of genetically compatible sperm.