Magnetically-Oriented Tissue-Equivalents: Mathematical Model and Application to an Arterial Media-Equivalent and Guided Nerve Regeneration

9522758特兰基罗该项目正在进行研究，为磁性定向组织等效物的制造和评估提供基础。研究人员先前发展了一种组织等效物的各向异性双相理论，该理论将被用于优化构建磁性定向动脉介质等效物的制造参数。此外，还将开发一种用于引导神经再生的磁性胶原管。这项研究涉及使用组织等效物的连续力学模型来描述细胞牵引、网络变形、原纤维和细胞取向之间的相互作用，以优化研究设计。***

9522758 Tranquillo This project is on research to provide a foundation for the fabrication and evaluation of magnetically-oriented tissue- equivalents. The investigator has previously developed an anisotropic biphasic theory of tissue-equivalents which will be used to optimize the fabrication parameters for the construction of a magnetically-oriented arterial media- equivalent. Also, a magnetically-oriented collagen tube for guided nerve regeneration will be developed. This research involves the use of a continuum mechanical model of tissue equivalents describing the interplay between cell traction, network deformation, and fibril and cell orientation to optimize the research design. ***