Magnetically-Oriented Tissue-Equivalents: Mathematical Model and Application to an Arterial Media-Equivalent and Guided Nerve Regeneration

磁定向组织等效物：数学模型及其在动脉介质等效物和引导神经再生中的应用

• 批准号: 9522758
• 负责人: Robert Tranquillo
• 金额: $ 48.49万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-10-01 至 1999-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9522758&HistoricalAwards=false
• 关键词: Magnetically; Oriented; Tissue; Equivalents; Mathematical

9522758 Tranquillo This project is on research to provide a foundation for the fabrication and evaluation of magnetically-oriented tissue- equivalents. The investigator has previously developed an anisotropic biphasic theory of tissue-equivalents which will be used to optimize the fabrication parameters for the construction of a magnetically-oriented arterial media- equivalent. Also, a magnetically-oriented collagen tube for guided nerve regeneration will be developed. This research involves the use of a continuum mechanical model of tissue equivalents describing the interplay between cell traction, network deformation, and fibril and cell orientation to optimize the research design. ***

9522758特兰基罗该项目正在进行研究，为磁性定向组织等效物的制造和评估提供基础。研究人员先前发展了一种组织等效物的各向异性双相理论，该理论将被用于优化构建磁性定向动脉介质等效物的制造参数。此外，还将开发一种用于引导神经再生的磁性胶原管。这项研究涉及使用组织等效物的连续力学模型来描述细胞牵引、网络变形、原纤维和细胞取向之间的相互作用，以优化研究设计。***