Research Initiation: The Neutrophil Model for Growth FactorSignalling

研究启动奖：生长因子信号传导的中性粒细胞模型通过细胞内信使的信号转导，以及细胞内信使与细胞功能反应的耦合是一个密集的实验研究领域。本研究的中心目标是将哺乳动物细胞感觉系统多形核中性粒细胞（PMN）的上述过程的现有知识纳入受体介导的细胞反应的结构化数学模型中。这项研究将提高对刺激-反应耦合中生物化学和生物物理事件相互关系的理解，这些事件通常是单独研究的，但很少被集体考虑。

RESEARCH INITIATION AWARD: THE NEUTROPHIL MODEL FOR GROWTH FACTOR SIGNALLING ABSTRACT Understanding mechanisms of surface receptor signal generation, signal transduction via intracellular messengers, and coupling of intracellular messengers to cell functional responses is an area of intensive experimental research. The central goal of the proposed research is to incorporate current knowledge of the above processes for a mammalian cell sensory system, the polymorphonuclear neutrophil (PMN), into structured mathematical models of receptor-mediated cell responses. This research will improve understanding of the interrelationships of biochemical and biophysical events in stimulus-response coupling which are often investigated individually but seldom considered collectively.