Research Initiation: The Neutrophil Model for Growth FactorSignalling

研究启动奖： 生长因子信号转导的中性粒细胞模型 摘要 了解表面受体信号产生的机制， 通过细胞内信使的信号转导，以及 细胞内信使到细胞功能反应是一个区域， 密集的实验研究。 的中心目标 拟议的研究是将上述现有知识 哺乳动物细胞感觉系统的过程， 中性粒细胞（PMN），结构化数学 受体介导的细胞反应模型。 这项研究将 提高对生物化学和生物医学之间相互关系的理解， 刺激-反应耦合中的生物物理事件， 单独调查，但很少集体考虑。

RESEARCH INITIATION AWARD: THE NEUTROPHIL MODEL FOR GROWTH FACTOR SIGNALLING ABSTRACT Understanding mechanisms of surface receptor signal generation, signal transduction via intracellular messengers, and coupling of intracellular messengers to cell functional responses is an area of intensive experimental research. The central goal of the proposed research is to incorporate current knowledge of the above processes for a mammalian cell sensory system, the polymorphonuclear neutrophil (PMN), into structured mathematical models of receptor-mediated cell responses. This research will improve understanding of the interrelationships of biochemical and biophysical events in stimulus-response coupling which are often investigated individually but seldom considered collectively.