STTR: Analytical Microseparations with Nuclear Magnetic Resonance Detection

9523220 Peck这项研究是为了扩展目前的核磁共振检测单元模型，以获得两个数量级的灵敏度改进。目前的核磁共振谱仪灵敏度较低，限制了其作为微量分离检测器的应用。新的电池将采用特别设计的RF微线圈，用于流动分析分离，同时保留用于结构确定的全部核磁共振能力。这使得细胞能够分析质量受限和体积受限的化学物种样本。这项研究的总体目标是创建新一代优化的纳升体积核磁共振检测单元，用于用于液相色谱和毛细管电泳微分离研究的商业化。

9523220 Peck This research is to extend current models of nuclear magnetic resonance (NMR) detection cells to obtain a two order of magnitude improvement in sensitivity. The current NMR spectroscope has limited application as a detector for microseparations because of its relatively poor sensitivity. The new cells will employ specially designed RF microcoils that will be used in flowing analytical separation while retaining the full NMR capability for structural determination. This enables the cells to analyze mass-limited and volume-limited samples of chemical species. The overall goal of this research is to create a new generation of optimized nanoliter volume NMR detection cells for commercialization for liquid chromatography and capillary electrophoresis microseparation studies.