Laboratory for Molecular Sciences (LMS): Caltech's Multi-Disciplinary Activities for Studies of Fundamental Processes in Complex Systems

分子科学实验室 (LMS)：加州理工学院复杂系统基本过程研究的多学科活动

• 批准号: 9525756
• 负责人: Ahmed Zewail
• 金额: $ 600万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9525756&HistoricalAwards=false
• 关键词: Laboratory; Molecular; Sciences; LMS; Caltech

This award from the Division of Chemistry and the Office of Multidisciplinary Activities of the Directorate of Mathematical and Physical Sciences supports the research of Professor Ahmed Zewail and colleagues at the California Institute of Technology for the establishment of a multidisciplinary research laboratory for the study of fundamental processes in complex molecular systems with atomic scale resolution. The Laboratory for Molecular Science (LMS) will involve eight members of the Cal Tech faculty and will involve research in the following five thrust areas: 1) Dynamics of Ionic Solvation and Weak Interactions; 2) Femtosecond Dynamics by Photoelectron and Photodetachment Spectroscopy; 3) Structure and Dynamics of Electrocatalysts and Interfaces; 4) Atomic-scale Structure and Function of Receptor Proteins; 5) Electron and Energy Transfer in DNA and Condensed Phases. The purpose of the LMS is to advance the understanding of molecular and biological function in the five thrust areas at the microscopic level for complex molecular systems. The LMS will bring to bear state-of-the-art instruments with temporal and spatial resolution at the atomic scale. Femtosecond time resolution achieved with light, electron, and eventually X-rays will make it possible to relate structures at the most fundamental level to functions in real systems. In addition to the Principal Investigator, Ahmed Zewail, the members of the LMS include Fred C. Anson, Jacqueline K. Barton, Dennis A. Dougherty, Rudolph A. Marcus, B. Vincent McKoy, Mitchio Okumura, and Douglas C. Rees. Over the last 15 years great strides have been made in both spatial and temporal resolution of chemical systems down to the atomic scale. This capability has provided new opportunities for studying molecular structure and dynamics in chemistry and biology. From the elementary dynamics of reactions and protein folding to the dynamics of molecular assemblies and condensed phases, theory and experiment at the fundamental scale of atomic resolution provides the key to our understanding of molecular function and materials properties. The field of molecular sciences is indeed witnessing a revolution, especially at the interface between chemistry and biology where new experimental tools can be exploited to elucidate the structure and dynamics of complex molecular systems.

这项由数学和物理科学局化学司和多学科活动办公室颁发的奖项支持了加利福尼亚州理工学院Ahmed Zewail教授及其同事的研究，以建立一个多学科研究实验室，研究具有原子尺度分辨率的复杂分子系统的基本过程。分子科学实验室(LMS)将包括加州理工学院的8名成员，将涉及以下五个主要领域的研究：1)离子溶剂化和弱相互作用的动力学；2)光电子和光分离光谱的飞秒动力学；3)电催化剂和界面的结构和动力学；4)受体蛋白质的原子级结构和功能；5)DNA和凝聚态中的电子和能量转移。LMS的目的是促进对复杂分子系统在微观水平上五个推力领域的分子和生物功能的理解。LMS将带来原子尺度上具有时间和空间分辨率的最先进的仪器。利用光、电子以及最终的X射线所获得的飞秒时间分辨率将使在最基本水平上的结构与真实系统中的功能相关联成为可能。除了首席调查员艾哈迈德·泽维尔，LMS的成员还包括弗雷德·C·安森、杰奎琳·K·巴顿、丹尼斯·A·道格蒂、鲁道夫·A·马库斯、B·文森特·麦科伊、大村光雄和道格拉斯·C·里斯。在过去的15年里，化学体系的空间和时间分辨率都取得了长足的进步，精确到原子尺度。这种能力为研究化学和生物学中的分子结构和动力学提供了新的机会。从反应和蛋白质折叠的基本动力学到分子组装和凝聚相的动力学，原子分辨基本尺度的理论和实验为我们理解分子功能和材料性质提供了关键。分子科学领域确实正在经历一场革命，特别是在化学和生物学之间的界面上，人们可以利用新的实验工具来阐明复杂分子系统的结构和动力学。