Developing specific motoneuron subtypes from embryonic stem cells, and induced pluripotent stem cells, to treat neuromuscular disorders and paralysis due to injury.
Developing specific motoneuron subtypes from embryonic stem cells, and induced pluripotent stem cells, to treat neuromuscular disorders and paralysis due to injury.
从胚胎干细胞和诱导多能干细胞中开发特定的运动神经元亚型，以治疗神经肌肉疾病和损伤引起的瘫痪。
批准号：
205851
负责人：
Rafuse Victor F
金额：
$28.57万
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2010
资助国家：
加拿大
项目状态：
已结题
起止时间：
2010-03-01 至 2015-03-01
中文摘要
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英文摘要
Motor neuron diseases such as amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative disorders caused by the selective loss of motoneurons. As spinal motoneurons die, muscles become progressively weaker, to the point of complete paralysis,
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Humanization of skeletal muscle innervation to study ALS
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批准号：450942
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项目类别：Operating Grants
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资助金额：$65.76万
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财政年份：2021
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负责人：Rafuse Victor F
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依托单位：
Deciphering the mechanisms underlying synaptic dysfunction at the neuromuscular junction in Amyotrophic Lateral Sclerosis (ALS)
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批准号：344599
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项目类别：Operating Grants
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资助金额：$49.29万
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财政年份：2016
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负责人：Rafuse Victor F
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依托单位：
Restoring useful function to complete and permanently denervated skeletal muscles
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批准号：342891
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项目类别：Operating Grants
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资助金额：$52.63万
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财政年份：2016
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负责人：Rafuse Victor F
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依托单位：
Optical control of dysfunctional muscles
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批准号：332999
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项目类别：Operating Grants
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资助金额：$7.29万
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财政年份：2015
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负责人：Rafuse Victor F
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依托单位：
海外基金
