Novel Beta-Lactam Forming Reactions. Studies on Destabilized Carbocations and Intermediates Derived from Diazirines

新型β-内酰胺形成反应。

• 批准号: 9525943
• 负责人: Xavier Creary
• 金额: $ 29.4万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-15 至 1999-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9525943&HistoricalAwards=false
• 关键词: Novel; Beta; Lactam; Forming; Reactions.

With funding from the Organic Dynamics Program, Professor Creary of Notre Dame University will investigate the mechanisms regarding the novel heterocyclic compound formation derived from allowing halodiazirines to react with the xanthate ion. Further, attempts will be made to generate C-centered diazirinyl anions and to determine their thermal stability. This is of interest as these compounds are antiaromatic anions. Finally, the project will investigate the means to expand the scope of the beta-lactam forming reaction that was recently discovered by the author. Synthetic sequences which are new and yield novel products of general interest provide scientists with alternatives to new drugs and materials. This project addresses this point and describes further how these concepts can be used to generalize the methodology. Namely, a mechanistic understanding of the reaction will enable scientists to generalize and expand the scope of the original discovery. Since these heterocyclic compounds involve nitrogen, they are physiologically significant

在有机动力学项目的资助下， 达姆大学将调查有关小说的机制 通过使卤代二氮杂环丙烷 与黄原酸根离子反应。此外，将尝试生成 以C为中心的重氮丙环阴离子，并测定其热稳定性。 这是令人感兴趣的，因为这些化合物是反芳族阴离子。最后， 该项目将研究如何扩大 β-内酰胺形成反应是作者最近发现的。 合成序列是新的，并产生新的一般产物， 兴趣为科学家提供了新药物和新材料的替代品。 本项目解决了这一点，并进一步描述了这些 概念可用于概括该方法。也就是说， 对反应的理解将使科学家能够概括和 扩大了原始发现的范围由于这些杂环 化合物涉及氮，它们具有生理学意义，