Novel Beta-Lactam Forming Reactions. Studies on Destabilized Carbocations and Intermediates Derived from Diazirines

在有机动力学项目的资助下，圣母大学的Creary教授将研究允许卤代二氮嘧啶与黄原酸盐离子反应而产生的新型杂环化合物形成的机制。此外，将尝试生成c中心重氮酰阴离子并确定其热稳定性。这很有趣，因为这些化合物是反芳香阴离子。最后，该项目将研究扩大作者最近发现的β -内酰胺形成反应范围的方法。合成序列是新的，产生了普遍感兴趣的新产品，为科学家提供了新的药物和材料的替代品。本项目解决了这一点，并进一步描述了如何使用这些概念来概括方法。也就是说，对反应的机械理解将使科学家能够推广和扩大原始发现的范围。由于这些杂环化合物含有氮，因此具有重要的生理意义

With funding from the Organic Dynamics Program, Professor Creary of Notre Dame University will investigate the mechanisms regarding the novel heterocyclic compound formation derived from allowing halodiazirines to react with the xanthate ion. Further, attempts will be made to generate C-centered diazirinyl anions and to determine their thermal stability. This is of interest as these compounds are antiaromatic anions. Finally, the project will investigate the means to expand the scope of the beta-lactam forming reaction that was recently discovered by the author. Synthetic sequences which are new and yield novel products of general interest provide scientists with alternatives to new drugs and materials. This project addresses this point and describes further how these concepts can be used to generalize the methodology. Namely, a mechanistic understanding of the reaction will enable scientists to generalize and expand the scope of the original discovery. Since these heterocyclic compounds involve nitrogen, they are physiologically significant