Novel Beta-Lactam Forming Reactions. Studies on Destabilized Carbocations and Intermediates Derived from Diazirines

在有机动力学项目的资助下，圣母大学的克里里教授将研究卤代二氮杂环化合物与黄药离子反应产生的新型杂环化合物的形成机理。此外，还将尝试生成以C为中心的二叠氮基阴离子并测定它们的热稳定性。这是有意义的，因为这些化合物是抗芳香族阴离子。最后，该项目将研究扩大作者最近发现的β-内酰胺形成反应范围的方法。合成序列是一种新的、产生人们普遍感兴趣的新产品的序列，为科学家提供了新药物和新材料的替代品。本项目解决了这一点，并进一步描述了如何使用这些概念来概括该方法。也就是说，对反应的机械论理解将使科学家能够概括和扩大最初发现的范围。由于这些杂环化合物涉及氮，它们具有重要的生理意义

With funding from the Organic Dynamics Program, Professor Creary of Notre Dame University will investigate the mechanisms regarding the novel heterocyclic compound formation derived from allowing halodiazirines to react with the xanthate ion. Further, attempts will be made to generate C-centered diazirinyl anions and to determine their thermal stability. This is of interest as these compounds are antiaromatic anions. Finally, the project will investigate the means to expand the scope of the beta-lactam forming reaction that was recently discovered by the author. Synthetic sequences which are new and yield novel products of general interest provide scientists with alternatives to new drugs and materials. This project addresses this point and describes further how these concepts can be used to generalize the methodology. Namely, a mechanistic understanding of the reaction will enable scientists to generalize and expand the scope of the original discovery. Since these heterocyclic compounds involve nitrogen, they are physiologically significant