Preparation of novel beta-lactam derivatives using efficient leaving group

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Recently, there is a tremendous amount of preparation of selenium-containing compounds because of not only interesting reactivity but also biological activity. In this study, we have developed novel selenating reagent prepared by the reaction of potassium p-methylselenobenzoate with 2-bromoethyl-trimethylsilane. Novel selenium-containing β-lactams were efficiently prepared by the reaction of alkenes and alkynes with Grubbs 2^<nd> gen. catalyst. And also the β-lactams were obtained via the regioselective iodocyclization reaction from corresponding alkyne- and alkane-selenoureas. The synthesis of higher-membered selenium heterocycles such as seven- and eight-membered selenium-containing heterocycles has hardly been reported yet.