The Evolution of Cell, Organ, and Body Size Allometry

细胞、器官和身体尺寸异速生长的演变

• 批准号: 9528393
• 负责人: Robert Stevenson
• 金额: $ 2.5万
• 依托单位: University of Massachusetts Boston
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-10-01 至 1997-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9528393&HistoricalAwards=false
• 关键词: Evolution; Cell; Organ; Body; Size

9528392 Body size of animals is controlled by adjustments in cell size and cell number. We know relatively little about mechanisms that regulate cell size and cell division to yield an animal of a particular size. This research seeks to understand the relative importance of changes in cell size and cell number during evolutionary changes in body size, and to identify the genes that control such changes. It will focus on Drosophila because they exhibit a wide range of sizes and because of the extensive data that exist on their genetics and developmental biology. Measurements of cell size and number during development of imaginal discs will identify the developmental steps that lead to changes in body size. A comparative analysis will identify the pattern of evolution of body size differences, and a hybridization study will seek to map the genes that control body size. The results will increase our understanding of the factors that control body size, and the mechanisms that lead to changes in cell size and body size of animals.

9528392动物的身体大小是通过调节细胞大小和细胞数量来控制的。我们对调节细胞大小和细胞分裂以产生特定大小动物的机制知之甚少。这项研究试图了解细胞大小和细胞数量的变化在体型进化变化过程中的相对重要性，并确定控制这种变化的基因。它将专注于果蝇，因为它们展示了广泛的大小，而且存在着关于它们的遗传学和发育生物学的广泛数据。在形象盘的发育过程中对细胞大小和数量的测量将确定导致身体大小变化的发育步骤。比较分析将确定体型差异的进化模式，杂交研究将寻求绘制控制体型的基因图谱。这些结果将增加我们对控制身体大小的因素的理解，以及导致动物细胞大小和身体大小变化的机制。