Involvement of PDB3 and PDB4-related genes in bone diseases

PDB3和PDB4相关基因与骨疾病的关系

• 批准号: 225628
• 负责人: Michou Laetitia N
• 金额: $ 24.53万
• 依托单位: Centre hospitalier de l'Universit Laval (Qubec)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-03-01 至 2014-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=225628&lang=en
• 关键词: Alternative Splicing; Bone Resorption; Gene Expression; Metabolic Bone Diseases; Mutation; Osteoclast; Osteoclast Survival; Paget'S Disease Of Bone; Somatic Mosaicism; Sqstm1/P62 Protein

Paget's disease of bone (PDB) is the second most frequent bone disorder after osteoporosis, affecting approximately three percent of people over 55 years of age. Disabling complications of PDB, such as bone deformity, bone pain and fractures occur in abou

佩吉特骨病（PDB）是仅次于骨质疏松症的第二大常见骨病，约有3%的55岁以上人群患有此病。PDB的致残性并发症，如骨畸形、骨痛和骨折发生在约100例患者中。