The Reactivity of Metal-Oxo and Metal-Imido Groups

本研究的重点是确定的基本模式， 含氧和亚氨基的过渡金属配合物的反应性 功能协调发展的 化学计量锇化反应的详细动力学分析 将进行反应，并通过电化学研究进行增强。 在 另一组涉及锇催化的二羟基化的实验， X射线晶体学和微量热法将用于提供 生物碱配体与烯烃配位的证据 印刷受体. 最后，研究了氨羟化的催化方法， 将优化通过锇（VIII）物质的烯烃。有了这个奖， 有机合成项目正在支持K博士的研究巴里 斯克里普斯诊所化学系的夏普勒斯和 研究基金会。 夏普勒斯教授将把他的工作重点放在 阐明过渡金属反应性的基本机理 含有金属-杂原子多重键的络合物。 大幅 大量的努力将集中在四氧化锇与 在配位叔胺存在下的烯烃。 该反应 作为一种引入立体基因的方法， 有机分子的中心。 然而，我们实际上对 这个过程是如何发生的……

The focus of this research is to identify the fundamental modes of reactivity of transition metal complex containing oxo and imido functions. Detailed kinetic analyses of stoichiometric osmylation reactions will be performed, augmented by electrochemical studies. In another set of experiments involving osmium -catalyzed dihydroxylation , X-ray crystallography and microcalorimetry will be used to provide evidence about complexation between alkaloid ligands and olefinic substrates. Finally, the catalytic method for the aminohydroxylation of alkenes via an osmium (VIII) species will be optimized. With this award, the Synthetic Organic Program is supporting the research of Dr. K. Barry Sharpless of the Department of Chemistry at the Scripps Clinic and Research Foundation. Professor Sharpless will focus his work on elucidating the fundamental mechanism of reactivity of transition metals complexes containing metal-heteroatom multiple bonds. A substantial amount of the effort will focus on the reaction of osmium tetroxide with alkenes in the presence of coordinating tertiary amines. This reaction has achieved prominence as a method for the introduction of stereogenic centers into organic molecules. Yet very little is actually known about how this process occurs..