New Metal Catalyzed Organic Transformations

有机合成计划支持K博士的工作。巴里 夏普勒斯 麻省理工学院化学教授夏普勒斯继续他的 有机化学新试剂的开拓性研究 合成. 他目前的工作部分是针对 研究金属如何与分子中的现有基团络合 将新的反应引导到特定的位置。 值得注意的新 方向包括尝试开发方法， 需要一个现有的系绳来引导化学反应。 夏普勒斯的研究小组继续研究 配体加速催化反应的细节，以及如何 这导致观察到的显著的对映选择性， 反应。作为他的机械研究的一部分， 最近发现了一种将分离的 烯键，而无需事先将试剂结合到 衬底 这一发现开启了一个全新的竞技场， 科学探索，并具有巨大的合成潜力， 化学家 他的团队也在试图了解 这个过程。 夏普勒斯将“梳理元素周期表” 寻找新的试剂添加到武器库中 合成化学家可以得到。 初步审查将是 致力于寻找独特的金属/氢过氧化物组合， 对分离的烯烃进行不对称环氧化。 一个独特 分析系统，类似于用于筛选 分子的生物活性，将被用来检查大的 一系列的反应。

The Organic Synthesis Program supports the work of Dr. K. Barry Sharpless. Sharpless, Prof. of Chemistry at MIT, continues his pioneering investigations of new reagents for organic synthesis. His current work is, in part, directed towards examining how metals complex to existing groups in a molecule to direct new reactions to a particular site. Notable new directions include trying to develop methods that do not require an existing tether to direct the chemistry. Sharpless's group continues to investigate the mechanistic details of ligand-accelerated catalysis of reactions, and how this leads to the remarkable enantioselectivity observed for the reactions. As part of his mechanistic investigations he has recently discovered a process for dihydroxylating an isolated alkene bond without prior binding of the reagent to the substrate. This discovery opens a whole new arena for scientific enquiry, and has great potential for synthetic chemists. His group is trying to also understand the origins of this process. Sharpless will "comb the periodic table" looking for new reagents to add to the arsenal already available to the synthesis chemist. Initial scrutiny will be given to finding unique metal/ hydroperoxide combinations to carry out asymmetric epoxidation to isolated alkenes. A unique assay system, analgous to that used for screening for bioactivity of molecules, will be employed to examine large series of reactions.