Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry in Macromolecule Synthesis and Fabrication

聚合物是我们日常生活中非常有用的材料。 聚合物是通过化学方法将积木连接成非常大的结构，类似于孩子使用乐高积木建造和创建建筑物。 该研究项目的重点是开发以高效方式连接聚合物结构单元的反应。在温和的反应条件下。 该项目的另一个重要目标是增加妇女，代表性不足的少数民族，K-12学生和本科生在整个圣地亚哥社区的教育计划的参与。该项目涉及小学学生通过点击化学讲座/示范在小学科学研究所。 它还通过高中研究教育方案涉及当地高中学生。此外，该项目还为社区大学的学生提供了机会，通过为斯克里普斯研究所夏季本科生研究员（SURF）计划设计的新课程，开发点击化学。SuFEx化学是一种有用的点击反应，最近开发用于构建具有所需特性的结构多样化材料。磺酰/硫酰氟具有合成的可及性、稳定性和对质子或甲硅烷基活化剂的响应性的组合，质子或甲硅烷基活化剂是以微妙但强大的方式增强反应性的分子辅因子。 该项目的目标是探索使用SuFEx点击化学来制造具有不同化学结构的聚合物和树枝状材料的可行性。该项目有三个目标。第一个目标是寻找更好的催化剂，以促进需要更低的催化剂负载和更温和的反应条件的基于SuFEx的转化。第二个目标是使用在第一个目标下开发的SuFEx点击化学合成和官能化聚合物材料。第三个目标是制备基于SuFEx点击化学的树枝状材料。通过这些研究，本研究旨在了解SuFEx在构建大分子，超分子和纳米材料方面的优势和局限性，并建立模块化反应来构建这些分子。

Polymers are very useful materials in our daily life. Polymers are made by chemically connecting the building blocks into very large structures similar to a child using Legos to construct and create a building. This research project focuses on developing reactions that connect the polymer building blocks in a highly efficient manner. under mild reaction conditions. Another important goal of this project is to increase the participation of women, underrepresented minorities, K-12 students, and undergraduates in educational programs across the San Diego community. This project involves elementary school students through a click chemistry lecture / demonstration at the Elementary Institute of Science. It also involves local high school students through the High School Research Education Program. Additionally, the project provides opportunities for community college students to work on the development of click chemistry through a new curriculum designed for the Summer Undergraduate Research Fellows (SURF) Program at The Scripps Research Institute.SuFEx chemistry is a useful click reaction recently developed to construct structurally-diversified materials with desired properties. Sulfonyl/sulfuryl fluorides possess a combination of synthetic accessibility, stability, and responsiveness to the presentation of proton or silyl activators - molecular cofactors that enhance reactivity in subtle, yet powerful, ways. The goal of this project is to explore the feasibility of using SuFEx click chemistry to fabricate polymeric and dendritic materials with diverse chemical structures. There are three objectives in this project. The first objective is to search for better catalysts to promote SuFEx-based transformations requiring lower catalyst loading and milder reaction conditions. The second objective is to synthesize and functionalize polymeric materials using SuFEx click chemistry developed under the first objective. The third objective is to prepare dendritic materials based on SuFEx click chemistry. Through these studies, this research seeks to understand the strengths and limitations of SuFEx in the construction of macromolecular, supramolecular and nanoscopic materials, and to establish modular reactions to build these molecules.