Methods for Studying the Thermodynamics of Biotransformations Based on Group Contributions and Maximal Rates

基于群体贡献和最大速率的生物转化热力学研究方法

• 批准号: 9531787
• 负责人: Michael Mavrovouniotis
• 金额: $ 12.77万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-15 至 1999-09-15
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9531787&HistoricalAwards=false
• 关键词: Methods; Studying; Thermodynamics; Biotransformations; Based

9531787 Mavrovouniotis This project is aimed at the development and implementation of systematic techniques for the thermodynamic analysis of biochemical reactions and pathways. This proposal has three components: (1) determination of the standard (biological) Gibbs energy of formation of any biochemical compound from its structure, based on contributions of groups; (2) determination of the standard (biological) Gibbs energy change and the equilibrium constant of a biotransformation, from groups that occur in the metabolites involved; and (3) a technique that translates thermodynamic limitations to limitations on bioreaction rates, allowing the interpretation of the potential effect of thrmodynamics on observable parameters. ***

这个项目旨在开发和实施生化反应和途径热力学分析的系统技术。该提案有三个组成部分：(1)根据基团的贡献，从任何生化化合物的结构中确定其标准（生物）吉布斯形成能；(2)确定标准（生物）吉布斯能量变化和生物转化的平衡常数，从相关代谢物中发生的基团；(3)一种将热力学限制转化为生物反应速率限制的技术，允许解释热力学对可观察参数的潜在影响。＊＊＊