A Series of Nested GC-MS Applications in the Introductory Chemistry Sequence

化学入门序列中的一系列嵌套 GC-MS 应用

• 批准号: 9550890
• 负责人: Phyllis Leber
• 金额: $ 2.39万
• 依托单位: Franklin and Marshall College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-15 至 1997-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9550890&HistoricalAwards=false
• 关键词: Series; Nested; GC; MS; Applications

This project designs a set of nested or interrelated experiments employing gas chromatography-mass spectrometry (GC-MS) as a technique that exposes students to the use of this versatile instrument at ever-increasing levels of sophistication. Because the intent is to incorporate GC-MS in the introductory general and organic chemistry laboratory sequences, an instrument-intensive research-like experience has been designed for each laboratory sequence around an interdisciplinary theme: Environmental Chemistry for the general chemistry laboratory (analysis of an artificial "gasoline" mixture followed by water and soil analyses contaminated with gasoline and/or pesticides) and Plant Assays for the organic chemistry laboratory (a fatty acid, methyl ester analysis of a plant extract using standards synthesized by the students and synthesis, identification, and characterization of a series of plant growth hormones). The assumption in designing each project in this manner is that students gain sufficient mastery in GC-MS by a sequential series of applications and that exposure to modern instrumentation, especially in a hands-on format, is highly desirable. The thematic basis for the projects creates links with the related disciplines of geosciences and biology. Many aspiring premeds take biology, if not geology courses, so the bridging laboratory concept helps those students see the relevance of their laboratory work from several disciplinary perspectives. In both the general and organic chemistry laboratory sequences, the organizational paradigm of "Synthesis, Structure, and Identification" is enhanced by the integration of the GC-MS with its dual capability of separation and identification.

该项目设计了一套嵌套或相互关联的实验，采用气相色谱-质谱（GC-MS）作为一种技术，让学生在不断提高的复杂程度上使用这种多功能仪器。 由于目的是将GC-MS纳入介绍性的一般和有机化学实验室序列，因此围绕跨学科主题为每个实验室序列设计了一个仪器密集的研究式体验： 一般化学实验室的环境化学（分析人工“汽油”混合物，然后进行受汽油和/或农药污染的水和土壤分析）和有机化学实验室的植物分析（使用学生合成的标准品对植物提取物进行脂肪酸，甲基酯分析以及一系列植物生长激素的合成，鉴定和表征）。 以这种方式设计每个项目的假设是，学生通过一系列连续的应用程序获得足够的GC-MS掌握，并且接触现代仪器，特别是以动手的形式，是非常可取的。 项目的专题基础与地球科学和生物学的相关学科建立了联系。 许多有抱负的premeds采取生物学，如果不是地质学课程，所以桥接实验室的概念可以帮助这些学生看到他们的实验室工作从几个学科的角度相关。 在一般和有机化学实验室序列中，“合成，结构和鉴定”的组织范式通过GC-MS与其分离和鉴定的双重能力的整合而得到增强。