Enhanced Microcalorimetry in Chemistry Laboratories

化学实验室中的增强型微量热法

• 批准号: 9551572
• 负责人: Gerald Van Hecke
• 金额: $ 2.62万
• 依托单位: Harvey Mudd College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-05-01 至 1997-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9551572&HistoricalAwards=false
• 关键词: Enhanced; Microcalorimetry; Chemistry; Laboratories

As a result of the project, microcalorimetry is being integrated into chemistry major laboratories. Calorimetry is among the most fundamental of physical measurements with extensive applications to biological and materials chemistry. Technological advances have so increased the sensitivity of calorimetric measurements to the point where convenient studies of the energy changes associated with living systems are possible for such phenomena as membrane formation and phase segregation/aggregation even with very small sample sizes. The initial experiments of the project allow students to grasp the nature and importance of energy changes in biological systems by determining enthalpies of micelle formation and the binding constants of proteins and suitable ligands. Moreover, we students measure the heat capacity of the novel memory metal alloy NiTi. The improved instrumentation also enhances carbon compounds and junior year laboratory programs through the introduction of purity determination using differential scanning calorimetry as well as the range of independent research projects for senior students.

由于这个项目，微量热法正在被纳入主要的化学实验室。量热法是最基本的物理测量方法之一，在生物化学和材料化学中有着广泛的应用。技术的进步提高了量热测量的灵敏度，以至于即使在很小的样本量下，也可以方便地研究与生命系统有关的能量变化，如膜形成和相分离/聚集。该项目的初始实验通过确定胶束形成的焓和蛋白质和合适配体的结合常数，使学生掌握生物系统中能量变化的本质和重要性。此外，我们的学生测量了新型记忆金属合金NiTi的热容。改进后的仪器还通过引入差示扫描量热法纯度测定以及高年级学生独立研究项目的范围，增强了碳化合物和大三的实验室项目。