Japan JSPS Program: In Vitro Evaluation of a Phospholipid Polymer for Medical Device Applications: International Research Fellow Award

日本 JSPS 项目：用于医疗器械应用的磷脂聚合物的体外评价：国际研究员奖

• 批准号: 9600325
• 负责人: Betsy Williams
• 金额: $ 0.73万
• 依托单位: Fellowships
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9600325&HistoricalAwards=false
• 关键词: Japan; JSPS; Program; Vitro; Evaluation

9600325 Williams This award supports a 12 month Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship for Dr. Betsy Newton-Williams at the Institute of Medical and Dental Engineering, Tokyo Medical and Dental University, Tokyo, Japan. Dr. Newton-Williams will work with Dr. Nobuo Nakabayashi, Director of the Division of Organic Materials, on a research project entitled "In Vitro Evaluation of a Phospholipid Polymer for Medical Device Applications." The proposed research will evaluate the use of (methacryloyloxyethyl phosphorylcholine) MPC copolymers as a surface enhancement to improve the performance of implants and inhibiting bacterial adhesion and cell attachment. The success of percutaneous implant devices has been limited due to attachment of the skin cells to the implant and excessive tissue growth around the implant. The implants also fail due to infection when bacteria adhere to the implant surface and gain access to the underlying tissue through the area between the skin and the implant. The objective of this research is to improve implant performance through the incorporation of an MPC copolymer and the prevention of cell and bacterial attachment. Different methods of incorporating MPC polymers onto the surface of the bulk material will be examined. The distribution of MPC and the integrity of the MPC on the material surface will be evaluated during research, as well as in vitro protein adsorption, cellular attachment, and bacterial adherence. ***

9600325威廉姆斯该奖项支持日本科学促进会(JSPS)在日本东京医科大学医学与牙科工程研究所为贝齐·牛顿-威廉姆斯博士提供的为期12个月的博士后奖学金。牛顿-威廉姆斯博士将与有机材料部门主任Nobuo Nakabayashi博士合作开展一项名为“用于医疗器械的磷脂聚合物的体外评估”的研究项目。这项拟议的研究将评估(甲基丙烯酰氧乙基磷酰胆碱)MPC共聚物作为表面增强剂的用途，以改善植入物的性能，并抑制细菌黏附和细胞黏附。由于皮肤细胞附着在植入物上以及植入物周围组织过度生长，经皮植入装置的成功受到了限制。当细菌附着在植入物表面并通过皮肤和植入物之间的区域进入底层组织时，植入物也会由于感染而失败。这项研究的目的是通过加入MPC共聚物来改善种植体的性能，并防止细胞和细菌附着。将研究将MPC聚合物加入到块状材料表面的不同方法。在研究期间，将评估MPC在材料表面的分布和MPC的完整性，以及体外蛋白质吸附、细胞附着和细菌附着。***