Fourth E. Coli and Small Genomes Meeting: to be held September 8-12, 1996, Lake Arrowhead, CA

9600796米勒E.到1996年底，大肠杆菌基因组分析工作可能会完成对这种经过充分研究的生物体的完整序列测定。 超过2800个基因和ORF已被测序;超过70%的染色体DNA及其基因产物，如果确定，在瑞士蛋白质数据库中。 广泛的遗传、生理和生化知识。大肠杆菌使其成为所有生物体中定义最明确的。 当我们接近E的总序列时，现在有机会整合这些信息体，这是非常令人兴奋的。coli DNA和所有基因产物。 此外，能够比较E。大肠杆菌的基因组序列与其他10个小基因组的序列相同。 为了进行整合，科学家们在E。不同区域的大肠杆菌会相互作用。 测序师、克隆师、遗传学家、细胞生理学家、生物化学家、数据库构建者和计算机科学家都来自不同的视角，现在正在融合。 这次会议将汇集在基因和序列一级分析基因组的主要研究人员，促进必要的互动，并将促进协调对这种生物体基因组的结构和功能分析。 参与H.流感病毒、支原体和7种不同的古菌也将展示他们的发现，为比较如此多的完整基因组的结果提供了前所未有的机会。 这次会议的目的是邀请和参与者发起的演讲，也将有实践研讨会，在此期间，来自不同学科的调查人员将能够熟悉现有的数据库和新的工具，促进分析和协调信息。 参与者不仅将在讲座中听到最新的信息，而且还将获得基于计算机的新能力的实践指导，以寻找和捕获，分析，关联和整合复杂的新信息。 该领域正在非常快速地获取基因组内容及其对细胞过程的重要性的新知识，以及信息的管理和分析，连接序列，遗传组织和调控的知识体系。 没有其他会议综合E.大肠杆菌的基因组序列、序列信息和数据库分析，以及与其他已完成的基因组序列的比较。 ***

9600796 Miller The E. coli genome analysis efforts are likely to achieve a complete sequence determination of the well studied organism by the end of 1996. Over 2800 genes and ORFs have been sequenced; over 70% of the chromosomal DNA, and their gene products, where identified, are in the Swiss Protein database. The extensive genetic, physiological and biochemical knowledge of E. coli make this the best defined of all organisms. There is much excitement surrounding the opportunity now to integrate these bodies of information as we approach total sequence of E. coli DNA and all gene products. Moreover, there is the added excitement of being able to compare the E. coli sequence with that of as many as 10 other small genomes. To carry out the integration, scientists working on E. coli in different areas will interact. The sequencers, cloners, geneticists, cell physiologists, biochemists, database builders and computer scientists all come from different perspectives that are now fusing. The meeting will facilitate the necessary interactions by bringing together leading researchers in the analysis of genomes at the genetic and sequence level, and will facilitate the coordination of the structural and functional analysis of this organism's genome. Participants in the complete sequencing of H. influenzae, mycoplasma, and 7 different archaea will also present their findings, affording the unprecedented opportunity to compare results from so many completed genomes. This meeting is designed to have a mix of invited and participant-initiated presentations, and will also have hands-on workshops during which investigators from different disciplines will be able to become familiar with available databases and new tools facilitating analysis and coordination of information. Participants will not only hear the latest information in the talks, but also will have available hands-on instruction in new computer-based abilities to seek out and capture, analyze, correlate and integrate complex new information. The fields are moving very fast both in acquisition of new knowledge of the contents of genomes and their significance to cellular processes and also in management and analysis of the information, connecting bodies of knowledge on sequences, genetic organization and regulation. No other meeting synthesizes the biology of E. coli, sequence information and database analysis, as well as the comparison with other completed genome sequences. ***