Fourth E. Coli and Small Genomes Meeting: to be held September 8-12, 1996, Lake Arrowhead, CA

[600796]米勒大肠杆菌基因组分析工作很可能在1996年年底前完成对这种已得到充分研究的有机体的完整序列测定。超过2800个基因和orf被测序；超过70%的染色体DNA和它们的基因产物，一旦被识别，就在瑞士蛋白质数据库中。大肠杆菌广泛的遗传、生理和生化知识使其成为所有生物体中定义最好的。当我们接近大肠杆菌DNA和所有基因产物的总序列时，现在有机会整合这些信息体是非常令人兴奋的。此外，能够将大肠杆菌序列与多达10个其他小基因组的序列进行比较是一件令人兴奋的事情。为了实现整合，在不同领域研究大肠杆菌的科学家将进行互动。测序者、克隆者、遗传学家、细胞生理学家、生物化学家、数据库建设者和计算机科学家都来自不同的视角，现在正在融合在一起。会议将汇集基因组分析的主要研究人员，在遗传和序列水平上促进必要的互动，并将促进这种生物体基因组的结构和功能分析的协调。参与流感嗜血杆菌、支原体和7种不同古菌完整测序的参与者也将展示他们的发现，提供前所未有的机会来比较如此多完整基因组的结果。本次会议的目的是混合邀请和参与者发起的演讲，还将有实践研讨会，在此期间，来自不同学科的研究人员将能够熟悉现有的数据库和促进信息分析和协调的新工具。参与者不仅可以在讲座中听到最新的信息，还可以在新的基于计算机的能力中获得实践指导，以寻找和捕获，分析，关联和整合复杂的新信息。在获取基因组内容的新知识及其对细胞过程的重要性方面，以及在信息的管理和分析方面，这些领域正在迅速发展，将序列、遗传组织和调控方面的知识体系联系起来。没有其他会议综合大肠杆菌的生物学，序列信息和数据库分析，以及与其他已完成的基因组序列的比较。＊＊＊

9600796 Miller The E. coli genome analysis efforts are likely to achieve a complete sequence determination of the well studied organism by the end of 1996. Over 2800 genes and ORFs have been sequenced; over 70% of the chromosomal DNA, and their gene products, where identified, are in the Swiss Protein database. The extensive genetic, physiological and biochemical knowledge of E. coli make this the best defined of all organisms. There is much excitement surrounding the opportunity now to integrate these bodies of information as we approach total sequence of E. coli DNA and all gene products. Moreover, there is the added excitement of being able to compare the E. coli sequence with that of as many as 10 other small genomes. To carry out the integration, scientists working on E. coli in different areas will interact. The sequencers, cloners, geneticists, cell physiologists, biochemists, database builders and computer scientists all come from different perspectives that are now fusing. The meeting will facilitate the necessary interactions by bringing together leading researchers in the analysis of genomes at the genetic and sequence level, and will facilitate the coordination of the structural and functional analysis of this organism's genome. Participants in the complete sequencing of H. influenzae, mycoplasma, and 7 different archaea will also present their findings, affording the unprecedented opportunity to compare results from so many completed genomes. This meeting is designed to have a mix of invited and participant-initiated presentations, and will also have hands-on workshops during which investigators from different disciplines will be able to become familiar with available databases and new tools facilitating analysis and coordination of information. Participants will not only hear the latest information in the talks, but also will have available hands-on instruction in new computer-based abilities to seek out and capture, analyze, correlate and integrate complex new information. The fields are moving very fast both in acquisition of new knowledge of the contents of genomes and their significance to cellular processes and also in management and analysis of the information, connecting bodies of knowledge on sequences, genetic organization and regulation. No other meeting synthesizes the biology of E. coli, sequence information and database analysis, as well as the comparison with other completed genome sequences. ***