Eighth Small Genomes Conference-2000 being held in Lake Arrowhead, California on September 24-28, 2000.

本提案是为将于2000年9月24日至28日在加利福尼亚州箭头湖会议中心举行的第八届小基因组会议（前身为大肠杆菌和小基因组会议）申请会议经费。在接下来的一两年里，比较多达50种微生物基因组的序列和内容的前景令人兴奋。毫无疑问，微生物学不同方面的大量整合将会发生，包括关于进化和生命需求的新观点。为了实现这些目标，特别是整合和协同，来自不同学科的科学家必须相互作用。因此，本次会议将包括活跃的基因组研究人员，如测序专家和信息学专家在数据库设计，序列分析，或模拟工作；遗传学家开发新方法，利用基因组信息进行功能分析；还有细胞生物学家和生物化学家，他们专门研究的领域现在已经成熟，比如代谢、染色体结构或基因调控。这次会议的一个重点也将是病原体的基因组。虽然最近已经召开了一些基因组会议，但新的基因组序列的不断完成和发布以及对这些大量信息进行分析的发展势头意味着社区仍然需要这样的会议。在过去的七年中，该会议已成为一个重要的年度微生物基因组学会议，并确保了地位和质量。

This proposal is for a conference grant for the eighth Small Genomes Conference (formerly the E. coli and Small Genomes Conference) to be held September 24-28, 2000, at the conference center in Lake Arrowhead, California. There is great excitement over the prospect of comparing the sequences and contents of as many as 50 microbial genomes over the next year or two. Considerable integration of different aspects of microbiology will undoubtedly take place, including new perspectives on evolution and the requirements for life. To achieve these goals, particularly of integration and synergy, scientists from diverse disciplines must interact. Thus, this conference will include active genome researchers, such as sequencing experts and informatics specialists working in database design, sequence analysis, or simulation; geneticists developing new methods to take advantage of genomic information for functional analysis; and cell biologists and biochemists who have specialized in areas now ripe for genomics such as metabolism, chromosome structure, or gene regulation. One focus of this conference will also be on genomes of pathogens. While there have been a number of recent genome conferences, continuing completion and release of new genome sequences and developing momentum for analysis of this huge amount of information means the community has continued need of such conferences. This meeting has become established as a major annual microbial genomics conference during the last seven years and has assured status and quality.