Eighth Small Genomes Conference-2000 being held in Lake Arrowhead, California on September 24-28, 2000.

该提案是为第八届小基因组会议（以前的大肠杆菌和小基因组会议）提供会议拨款，该会议将于 2000 年 9 月 24 日至 28 日在加利福尼亚州箭头湖会议中心举行。人们对于在未来一两年内比较多达 50 个微生物基因组的序列和内容的前景感到非常兴奋。毫无疑问，微生物学的不同方面将会发生相当大的整合，包括关于进化和生命要求的新观点。为了实现这些目标，特别是整合和协同作用，来自不同学科的科学家必须互动。因此，本次会议将包括活跃的基因组研究人员，例如从事数据库设计、序列分析或模拟工作的测序专家和信息学专家；遗传学家正在开发新方法，利用基因组信息进行功能分析；以及细胞生物学家和生物化学家，他们专门研究目前基因组学成熟的领域，如代谢、染色体结构或基因调控。本次会议的焦点之一还将是病原体基因组。虽然最近召开了许多基因组会议，但新基因组序列的不断完成和发布以及分析大量信息的发展势头意味着社区仍然需要此类会议。该会议在过去七年中已成为重要的年度微生物基因组学会议，并具有有保证的地位和质量。

This proposal is for a conference grant for the eighth Small Genomes Conference (formerly the E. coli and Small Genomes Conference) to be held September 24-28, 2000, at the conference center in Lake Arrowhead, California. There is great excitement over the prospect of comparing the sequences and contents of as many as 50 microbial genomes over the next year or two. Considerable integration of different aspects of microbiology will undoubtedly take place, including new perspectives on evolution and the requirements for life. To achieve these goals, particularly of integration and synergy, scientists from diverse disciplines must interact. Thus, this conference will include active genome researchers, such as sequencing experts and informatics specialists working in database design, sequence analysis, or simulation; geneticists developing new methods to take advantage of genomic information for functional analysis; and cell biologists and biochemists who have specialized in areas now ripe for genomics such as metabolism, chromosome structure, or gene regulation. One focus of this conference will also be on genomes of pathogens. While there have been a number of recent genome conferences, continuing completion and release of new genome sequences and developing momentum for analysis of this huge amount of information means the community has continued need of such conferences. This meeting has become established as a major annual microbial genomics conference during the last seven years and has assured status and quality.