Neuroimmune Interactions in the Visual Cortex During Development

9600974奈格勒了解导致神经系统形成精确连接的细胞和分子过程是神经科学的主要任务之一。这一建议针对的是这个普遍问题的一个关键方面：神经元活动、竞争和细胞-细胞竞争在胚胎大脑中的作用。在胚胎中建立的初始连接的重塑是在发育过程中完善大脑功能回路的过程的重要部分。很少有研究涉及免疫系统在这些过程中的作用。这项提案旨在探索特殊细胞的作用，这种小胶质细胞通常扮演清道夫的角色，攻击患病或受损的细胞。这一提议的工作假设是，小胶质细胞和相关的免疫系统分子可能在发育过程中神经连接的精细化过程中发挥作用。这项研究计划，作为职业奖励，将包括本科生参与实验室。

9600974 Naegele Understanding the cellular and molecular processes that lead to the formation of precise connections in the nervous system is one of the major tasks of neuroscience. This proposal is directed to one key aspect of the general problem: the role of neuronal activity, competition and cell-cell competition in the embryonic brain. Remodelling of the initial connections made in the embryo is an important part of the process by which the functioning brain circuits are refined during development. Few studies have addressed the role of the immune system in these processes. This proposal seeks to explore the role of special cells, the microglia that typically act as scavengers , attacking diseased or damaged cells. The working hypothesis for this proposal is that the microglia and associated immune system molecules may play a part in the refinement of neural connections during development. This research program, as a Career award, will involve undergraduate participation in the laboratory.