New vaccines and diagnostics to control viral disease in farmed crocodiles

控制养殖鳄鱼病毒性疾病的新疫苗和诊断方法

• 批准号: LP210301351
• 负责人: Dr Jody Hobson-Peters
• 金额: $ 61.84万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP210301351
• 关键词: New; vaccines; diagnostics; control; viral

Infection of farmed crocodiles with West Nile virus (WNV) causes lesions in the skin that render the hides unsuitable for high quality leather products. This results in >$20 million lost revenue to the Australian crocodile industry annually. We have developed a novel technology to generate safe and effective vaccines and diagnostic tests for WNV in animals. We aim to 1) conduct vaccine trials in farmed crocodiles to determine the optimum dose formulation and immunisation regime to provide long-lived protection against WNV disease; 2) validate pen-side tests to rapidly diagnose WNV infection in crocodiles on farms; and 3) transfer the technology to a manufacturing facility to ensure a commercial supply of the vaccines and diagnostic tests.

养殖鳄鱼感染西尼罗河病毒（WNV）会导致皮肤病变，使皮革不适合高质量的皮革产品。这导致澳大利亚鳄鱼业每年损失超过2000万美元的收入。我们开发了一种新技术，用于在动物中产生安全有效的疫苗和诊断测试。我们的目标是：1）在养殖鳄鱼中进行疫苗试验，以确定最佳剂量配方和免疫方案，以提供对WNV疾病的长期保护; 2）验证围栏测试，以快速诊断养殖场鳄鱼中的WNV感染; 3）将技术转移到生产设施，以确保疫苗和诊断测试的商业供应。