2023 RNA Nanotechnology Gordon Research Conference and Seminar

项目摘要 此R13应用程序要求部分资金，以支持即将举行的戈登研究会议（GRC）， RNA纳米技术，将于2023年1月8日至13日在加利福尼亚州文图拉举行，以及相关的戈登研究 研讨会（GRS），将于1月7日至8日举行。会议将由Louise Laurent和Sarah共同主持 伍德森于2017年1月在第二届RNA纳米技术GRC上当选，并担任 2019年1月，第三届GRC的联合副主席。原定于2021年举行的会议被GRC推迟 因为新冠疫情RNA纳米技术作为一个重要的领域继续发展， 正在进行的，以阐明基本原则，并制定创新的方法， 构建各种RNA纳米结构，以及应用RNA纳米技术解决 生物技术和医学的问题。发现和创新的步伐在过去只是加快了 两年RNA纳米技术是建立在RNA的独特性质，包括结构的多功能性，现有的 生物功能，易于功能化，这使得它成为一个理想的平台， 具有各种功能属性的自组装架构，适用于各种应用。本GRC重点 将RNA结构、组装和包装机制的基础研究与翻译 利用RNA纳米技术进行成像、诊断和治疗。 会议将分九次会议讨论一系列议题。RNA修饰与生物型，RNA 结构与组装和合成与编程核酸组装将以尖端研究为特色 基于核酸结构的分子基础，核酸纳米结构的设计和表征， 和生物物理学方法来研究和预测RNA折叠。核酸的新兴应用 在合成生物学中，作为功能装置和控制元件的结构将在以下会议中介绍： RNA适体、核糖开关和RNA成像。RNA封装和递送，RNA货物 细胞外囊泡的选择，基于RNA的生物标志物和诊断，以及RNA治疗将提供 展望了从细胞外囊泡和病毒中发现、分离和应用RNA， 强调天然和合成RNA在诊断和治疗发展中的翻译方面。 2023年大会将继续强调女性和少数民族科学家的强大代表性。的 受邀的演讲者和讨论领导者将包括该领域的知名研究人员和杰出的 来自世界各地的初级调查员。会议将向不同的受众做广告， 在RNA纳米技术和相关领域，早期职业和代表性不足的少数民族科学家。功率 一小时将以包容性和机会为主题。

PROJECT SUMMARY This R13 application requests partial funding to support the upcoming Gordon Research Conference (GRC) on RNA Nanotechnology, which will be held in Ventura, CA on Jan 8-13, 2023, and the associated Gordon Research Symposium (GRS), to precede it on Jan 7-8. The meeting will be co-chaired by Louise Laurent and Sarah Woodson, who were elected at the second GRC on RNA Nanotechnology in January 2017 and served as the co-vice chairs of the third GRC in January 2019. The conference planned for 2021 was postponed by the GRC due to the COVID pandemic. RNA nanotechnology continues to grow as an important field, with active research being carried out to elucidate basic principles of and develop innovative approaches to the design and construction of a variety of RNA nanostructures, as well as exciting work applying RNA nanotechnology to solving problems in biotechnology and medicine. The pace of discovery and innovation has only accelerated in the past two years. RNA nanotechnology is built upon unique properties of RNA, including structural versatility, existing biological functions, and ease of functionalization, which make it an ideal platform on which to build complex self-assembling architectures with a variety of functional attributes for diverse applications. This GRC focuses on linking fundamental studies on the mechanisms of RNA structure, assembly, and packaging to translational work using RNA nanotechnology in imaging, diagnostics, and therapeutics. The meeting will cover a range of topics in nine sessions. Sessions on RNA Modifications & Biotypes, RNA Structure & Assembly, and Synthetic & Programmed Nucleic Acid Assemblies will feature cutting-edge research on the molecular basis of nucleic acid architectures, design and characterization of nucleic acid nanostructures, and biophysical approaches to study and predict RNA folding. Emerging new applications of nucleic acid architectures as functional devices and as control elements in synthetic biology will be presented in sessions on RNA Aptamers & Riboswitches and RNA Imaging. Sessions on RNA Encapsulation & Delivery, RNA Cargo Selection in extracellular vesicles, RNA-based Biomarkers & Diagnostics, and RNA Therapeutics will provide perspectives on discovery, isolation and application of RNA from extracellular vesicles and viruses with an emphasis on translational aspects of natural and synthetic RNAs in development of diagnostics and therapeutics. The 2023 conference will continue to emphasize robust representation of women and minority scientists. The invited speakers and discussion leaders will include a mix of established researchers in the field and outstanding junior-level investigators from around the world. The meeting will be advertised to a diverse audience to include early career and under-represented minority scientists in the RNA nanotechnology and related fields. A Power Hour will feature topics of inclusion and opportunity.