U.S.-Korea Cooperative Research on Computational Fluid Dynamics for the Design and Optimization of Cardiac Assist Devices

该奖项将资助麻省理工学院机械工程系Roger D. Kamm博士与首尔国立大学生物医学工程系Byoung-Goo Min博士进行为期24个月的合作研究，以开发可用于辅助心脏辅助装置设计和优化的计算流体动力学方法。这位美国研究者将他的经验运用于计算方法分析心血管系统的流动，他使用的方法既适用于三维的、不稳定的流动，也适用于人工心脏或心室中发生的移动边界的流动。从制作到植入，再到在大型动物身上进行长期试验，在全人工心脏的开发过程中积累了丰富的经验。本研究的一个重要组成部分是实验验证和推广激光多普勒风速和粒子图像测速的数值模拟。这组合作者的综合专业知识将有助于开发可用于设计下一代心脏辅助设备的技术，这些设备可以优化流场，以减少血栓形成和溶血的趋势，同时最大限度地降低设备的功率要求。以前对植入式心脏辅助装置的研究已经取得了许多成功，但尚未导致可靠的全人工心脏。这个项目的前提是，下一代心脏辅助技术将需要新的工具，利用新开发的计算方法和实验能力。这个项目的合作者期望开发这些计算工具。该项目汇集了韩国生物医学工程专家和美国计算流体力学专家。他们将共同努力开发一种更小、更可靠、更有效的左心室辅助装置。该项目与美韩合作科学项目的目标相关，该项目旨在通过科学信息、思想、技能和技术的交流以及在互利问题上的合作，提高美韩科学家和工程师之间的合作水平。该项目为美国研究生提供国际研究经验。韩国的参与得到了韩国科学工程财团（KOSEF）的支持。＊＊＊

9602180 Kamm This award provides funds to permit Dr. Roger D. Kamm, Department of Mechanical Engineering, Massachusetts Institute of Technology, to pursue with Dr. Byoung-Goo Min, Department of Biomedical Engineering, Seoul National University, for 24 months, a program of cooperative research for the development of computational fluid dynamic methods that can be used to assist in the design and optimization of cardiac assist devices. The U.S. investigator brings his experience with use of computational methods for the analysis of flow in the cardiovascular system, using methods appropriate both for three-dimensional, unsteady flows with moving boundaries of the type that occur in the chambers of the artificial heart or the ventricle. The Korean collaborator and his research team bring to the research their considerable experience in the development of a total artificial heart, extending from fabrication of the device to implantation and long-term testing in large animals. An important component of this research is the experimental verification and extension of the numerical simulations using both laser Doppler anemometry and particle image velocimetry. The combined expertise of this group of collaborators will help in the development of techniques that can be used in the design of the next generation of cardiac assist devices which can be optimized with regard to the flow field to reduce the tendencies for thrombus formation and hemolysis, while minimizing the power requirements of the device. Previous research on implantable heart assist devices has produced many successes, but has not yet lead to a reliable total artificial heart. This project is based on the premise that the next generation of heart assist technology will require new tools that draw upon newly developed capabilities in computational methods and experimentation. The collaborators in this project expect to develop these computational tools. The project brings together Korean experts i n biomedical engineering and medicine and U.S. experts in computational fluid dynamics. Together they will attempt to develop a smaller, more reliable, and more efficient left ventricular assist device. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. This project provides an international research experience for a U.S. graduate student. Korean participation is supported by the Korea Science and Engineering Foundation (KOSEF). ***