Specific Degradation of Juvenile Hormone Esterase

保幼激素酯酶的特异性降解

• 批准号: 9602893
• 负责人: Bruce Hammock
• 金额: $ 1.18万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9602893&HistoricalAwards=false
• 关键词: Specific; Degradation; Juvenile; Hormone; Esterase

9602893 Hammock Specific Degradation of Juvenile Esterase Hormone The objective of this collaborative research project between Dr. Bruce Hammond of the University of California, Davis and Drs. John Oakeshott and Terry Hanzlik of the Division of Entomology, Black Mountain Institute of Plant Production and Processing, Canberra, Australia, is to examine the role of specific uptake and degradation of juvenile hormone esterase (JHE) in insect metamorphosis. The investigators will test the hypothesis that JHE titer is in part regulated by a specific and efficient system for its degradation. The first approach will involve the cloning and expression of the JHE from one or more evolutionary distant species of insects. A second step hypothesis will be tested regarding uptake and degradation based on a combination of chemical and molecular approaches. The long term goal of this research is to expand our knowledge of insect development. ***

小行星9602893 保幼酯酶激素的特异性降解 加州大学戴维斯分校的布鲁斯哈蒙德博士和澳大利亚堪培拉黑山植物生产和加工研究所昆虫学部的约翰·奥克肖特博士和特里·汉兹利克博士合作研究项目的目的是研究保幼激素酯酶（JHE）的特异性吸收和降解在昆虫变态中的作用。 研究人员将检验JHE滴度部分受其降解的特异性和有效系统调节的假设。第一种方法将涉及从一种或多种进化上遥远的昆虫物种克隆和表达JHE。 第二步假设将根据化学和分子方法的组合，对吸收和降解进行检验。 这项研究的长期目标是扩大我们对昆虫发育的了解。 ***