The Rpml Hypersensitive Cell Death Pathway in Arabidopsis Initiated by Pseudomonas syringae AvrB

拟南芥中由丁香假单胞菌 AvrB 启动的 Rpml 超敏细胞死亡途径

• 批准号: 9603814
• 负责人: Sheng He
• 金额: $ 20万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9603814&HistoricalAwards=false
• 关键词: Rpml; Hypersensitive; Cell; Death; Pathway

9603814 He During co-evolution of plants and their pathogens, plants have developed specific detection systems to detect pathogen presence by recognizing factors, products of co-called avr genes, whose recognition by the plant leads to responses. The model for Avr proteins often assumes that they are extracellular ligands and that the plants defense gene products are cell surface receptors. However, the model is not sufficiently supported by data. The work will address the recognition problem. Pseudomonas AvrB expressed inside a plant cell can trigger the pathogen response. Experiments will identify the intracellular receptor to which AvrB binds, and identify the low-molecular weight elicitor which is produced by the action of AvrB in transgenic plants.

9603814 He在植物及其病原体的共同进化过程中，植物已经开发出特定的检测系统，通过识别因子（所谓的avr基因的产物）来检测病原体的存在，植物对这些因子的识别会导致反应。 Avr蛋白的模型通常假设它们是细胞外配体，而植物防御基因产物是细胞表面受体。 然而，该模型没有得到数据的充分支持。 这项工作将解决识别问题。 在植物细胞内表达的假单胞菌AvrB可以触发病原体反应。 实验将鉴定AvrB结合的细胞内受体，并鉴定在转基因植物中由AvrB作用产生的低分子量激发子。