Pilot HGDP: Croos-Cultural Issues in Genetic Research with Plains Apaches: A Pilot Study for the Human Genome Diversity Project

这个项目的重点是伦理和法律的问题，遗传学研究在美国印第安人社区。首先，将与部落政府谈判涉及俄克拉荷马州阿帕奇部落的此类研究的条件。谈判将涉及以下问题：隐私、群体污名化、调查结果的公布、财产权和样本的处置。将研究个别部落成员对遗传学研究的反应。其次，研究将解决糖尿病易感性和癌症抵抗力。在皮马印第安人中首次发现的一种突变可能会影响肾上腺素的功能，从而导致糖尿病的风险。此外，雄性激素系统中的遗传变异可能会保护前列腺癌。将按照与部落商定的指导方针，对这些因素在这一人口健康中的作用进行测试。 糖尿病和癌症等疾病的预防需要改进。相关的发现可以从研究为什么不同人群的健康模式不同中产生。为了实现人类多样性基因组计划的这一目标，从不同的文化角度满足对研究的伦理关注至关重要。这项试点研究将探讨遗传学研究人员和土著社区如何合作。

This project focuses on ethical and legal issues for genetics research in an American Indian community. First, conditions for such research involving the Apache Tribe of Oklahoma will be negotiated with the tribal government. Negotiations will address the following issues: privacy, group stigmatization, publication of findings, property rights, and the disposition of samples. The response of individual tribal members to genetics research will be studied. Second, research will address susceptibility to diabetes and resistance to cancer. A mutation first found in Pima Indians may affect the function of adrenaline, contributing risk for diabetes. In addition, a genetic variant in the male hormone system may offer protection from prostate cancer. The role of these factors in the health of this population will be tested, following guidelines negotiated with the tribe. Prevention of diseases such as diabetes and cancer needs improvement. Relevant discoveries can arise from studying why health patterns vary in different populations. To achieve this goal of the Human Diversity Genome Project, it is crucial to satisfy ethical concerns about research from different cultural perspectives. This pilot study will explore how genetics researchers and indigenous communities can collaborate.