Field Enhanced Continuous Preparative Chiral Separation of Herbicide, Insecticide, and Fungicide Enantiomers for Reduced Environmental Burden

除草剂、杀虫剂和杀菌剂对映体的现场增强连续制备手性分离，以减少环境负担

• 批准号: 9613241
• 负责人: Arne Pearlstein
• 金额: $ 24万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-15 至 1999-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9613241&HistoricalAwards=false
• 关键词: Field; Enhanced; Continuous; Preparative; Chiral

CTS - 9613241 Arne Pearlstein University of Illinois Urbana-Champaign ABSTRACT The project is a combined computational and experimental effort at developing a generic field-enhanced continuous electrophoretic separation of chiral pesticides. The process is three-dimensional, and amplifies small electrophoretic mobility difference into large variations in azithumal displacement in an annulus, using an axisymmetric swirl flow. Enantioselective complexation with a chiral species provides the electrophoretic mobility difference. Computational work will focus on the effects of diffusion, field strength, geometry and swirl. Buoyant or electrohydrodynamic secondary flows will also be evaluated. The electrophoresis cell will be fabricated at NIST, where experiments will focus on the separation of herbicide enantiomers. The project may lead to an economical alternative to chiral separation for both commercial production and developmental testing. This will reduce the application levels of chiral pesticides and their environmental burden.

CTS - 9613241 Arne Pearlstein 伊利诺伊大学香槟分校 摘要 该项目是一项综合计算和实验工作，旨在开发手性农药的通用场增强连续电泳分离。 该过程是三维的，并使用轴对称旋流将小的电泳迁移率差异放大为环空中方位位移的大变化。 与手性物质的对映选择性络合提供了电泳迁移率差异。 计算工作将集中于扩散、场强、几何形状和漩涡的影响。 浮力或电流体动力二次流也将被评估。 电泳池将在 NIST 制造，实验重点是除草剂对映体的分离。 该项目可能会为商业生产和开发测试带来手性分离的经济替代方案。 这将减少手性农药的使用水平及其环境负担。