Speciation and Dynamics of the Peroxidase-Oxidase Oscillator

过氧化物酶-氧化酶振荡器的形态和动力学

• 批准号: 9615739
• 负责人: Alexander Scheeline
• 金额: $ 27.26万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9615739&HistoricalAwards=false
• 关键词: Speciation; Dynamics; Peroxidase; Oxidase; Oscillator

In this project in the Physical Chemistry Program of the Chemistry Division, Alexander Scheeline of the Department of Chemistry of the University of Illinois, Urbana will study the horseradish peroxidase oscillator using a reducing agent, oxygen as the oxidant, and cofactors such as methylene blue and 2,4-dichlorophenol. Recent work has led to semiquantitative understanding of this system. In the new research proposal new experiments will be conducted to elucidate fully the mechanism of this oscillating reaction and to be able to search for other biologically interesting chemical oscillators. Biochemical oscillators such as those studied in this project are of interest to unravel the mechanism of biological clocks, which are at the basis of important cellular transmission processes, although in that case also a membrane is involved.

在这个项目中的物理化学计划的化学 司，亚历山大Scheeline的化学系的 伊利诺伊大学厄巴纳分校将研究辣根过氧化物酶 使用还原剂、作为氧化剂的氧和辅因子的振荡器 例如亚甲蓝和2，4-二氯苯酚。最近的工作导致 半定量地了解这个系统。在这项新研究中 建议将进行新的实验，以充分阐明 这种振荡反应的机制，并能够寻找其他 有趣的化学振荡器 生物化学振荡器，如在这个项目中研究的那些， 兴趣解开生物钟的机制，这是在 重要的蜂窝传输过程的基础，尽管在这种情况下 还涉及膜。